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1bnl

From Proteopedia

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[[Image:1bnl.png|left|200px]]
 
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{{STRUCTURE_1bnl| PDB=1bnl | SCENE= }}
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==ZINC DEPENDENT DIMERS OBSERVED IN CRYSTALS OF HUMAN ENDOSTATIN==
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<StructureSection load='1bnl' size='340' side='right'caption='[[1bnl]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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===ZINC DEPENDENT DIMERS OBSERVED IN CRYSTALS OF HUMAN ENDOSTATIN===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1bnl]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BNL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BNL FirstGlance]. <br>
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{{ABSTRACT_PUBMED_9724722}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bnl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bnl OCA], [https://pdbe.org/1bnl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bnl RCSB], [https://www.ebi.ac.uk/pdbsum/1bnl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bnl ProSAT]</span></td></tr>
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[[1bnl]] is a 4 chain structure of [[Collagen]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BNL OCA].
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/COIA1_HUMAN COIA1_HUMAN] Defects in COL18A1 are a cause of Knobloch syndrome type 1 (KNO1) [MIM:[https://omim.org/entry/267750 267750]. An autosomal recessive disorder defined by the occurrence of high myopia, vitreoretinal degeneration with retinal detachment, macular abnormalities and occipital encephalocele.<ref>PMID:10942434</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/COIA1_HUMAN COIA1_HUMAN] COLA18A probably plays a major role in determining the retinal structure as well as in the closure of the neural tube. Endostatin potently inhibits endothelial cell proliferation and angiogenesis. May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bn/1bnl_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bnl ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Collagen|Collagen]]
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*[[Collagen 3D structures|Collagen 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:009724722</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Boehm, T.]]
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[[Category: Large Structures]]
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[[Category: Chopra, R.]]
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[[Category: Boehm T]]
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[[Category: Ding, Y H.]]
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[[Category: Chopra R]]
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[[Category: Folkman, J.]]
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[[Category: Ding Y-H]]
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[[Category: Harris, B A.]]
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[[Category: Folkman J]]
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[[Category: Hohenester, E.]]
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[[Category: Harris BA]]
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[[Category: Javaherian, K.]]
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[[Category: Hohenester E]]
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[[Category: Lanciotti, J.]]
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[[Category: Javaherian K]]
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[[Category: Li, Y.]]
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[[Category: Lanciotti J]]
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[[Category: Lo, K M.]]
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[[Category: Li Y]]
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[[Category: Shapiro, R.]]
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[[Category: Lo K-M]]
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[[Category: Timpl, R.]]
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[[Category: Shapiro R]]
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[[Category: Wiley, D C.]]
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[[Category: Timpl R]]
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[[Category: Angiogenic]]
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[[Category: Wiley DC]]
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[[Category: Angiogenisis]]
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[[Category: Antiangiogenic]]
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[[Category: Cancer]]
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[[Category: Collagen]]
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[[Category: Collagen xviii]]
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[[Category: Endostatin]]
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[[Category: Extracellular matrix]]
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Current revision

ZINC DEPENDENT DIMERS OBSERVED IN CRYSTALS OF HUMAN ENDOSTATIN

PDB ID 1bnl

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