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1bnl

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(New page: 200px<br /> <applet load="1bnl" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bnl, resolution 2.9&Aring;" /> '''ZINC DEPENDENT DIMER...)
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[[Image:1bnl.gif|left|200px]]<br />
 
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<applet load="1bnl" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1bnl, resolution 2.9&Aring;" />
 
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'''ZINC DEPENDENT DIMERS OBSERVED IN CRYSTALS OF HUMAN ENDOSTATIN'''<br />
 
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==Overview==
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==ZINC DEPENDENT DIMERS OBSERVED IN CRYSTALS OF HUMAN ENDOSTATIN==
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The crystal structure of human endostatin reveals a zinc-binding site., Atomic absorption spectroscopy indicates that zinc is a constituent of, both human and murine endostatin in solution. The human endostatin zinc, site is formed by three histidines at the N terminus, residues 1, 3, and, 11, and an aspartic acid at residue 76. The N-terminal loop ordered around, the zinc makes a dimeric contact in human endostatin crystals. The, location of the zinc site at the amino terminus, immediately adjacent to, the precursor cleavage site, suggests the possibility that the zinc may be, involved in activation of the antiangiogenic activity following cleavage, from the inactive collagen XVIII precursor or in the cleavage process, itself.
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<StructureSection load='1bnl' size='340' side='right'caption='[[1bnl]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1bnl]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BNL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BNL FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bnl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bnl OCA], [https://pdbe.org/1bnl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bnl RCSB], [https://www.ebi.ac.uk/pdbsum/1bnl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bnl ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/COIA1_HUMAN COIA1_HUMAN] Defects in COL18A1 are a cause of Knobloch syndrome type 1 (KNO1) [MIM:[https://omim.org/entry/267750 267750]. An autosomal recessive disorder defined by the occurrence of high myopia, vitreoretinal degeneration with retinal detachment, macular abnormalities and occipital encephalocele.<ref>PMID:10942434</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/COIA1_HUMAN COIA1_HUMAN] COLA18A probably plays a major role in determining the retinal structure as well as in the closure of the neural tube. Endostatin potently inhibits endothelial cell proliferation and angiogenesis. May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bn/1bnl_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bnl ConSurf].
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<div style="clear:both"></div>
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==Disease==
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==See Also==
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Known disease associated with this structure: Knobloch syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=120328 120328]]
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*[[Collagen 3D structures|Collagen 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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1BNL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ZN as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BNL OCA].
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__TOC__
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</StructureSection>
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==Reference==
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Zinc-dependent dimers observed in crystals of human endostatin., Ding YH, Javaherian K, Lo KM, Chopra R, Boehm T, Lanciotti J, Harris BA, Li Y, Shapiro R, Hohenester E, Timpl R, Folkman J, Wiley DC, Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10443-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9724722 9724722]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Boehm, T.]]
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[[Category: Boehm T]]
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[[Category: Chopra, R.]]
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[[Category: Chopra R]]
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[[Category: Ding, Y.H.]]
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[[Category: Ding Y-H]]
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[[Category: Folkman, J.]]
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[[Category: Folkman J]]
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[[Category: Harris, B.A.]]
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[[Category: Harris BA]]
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[[Category: Hohenester, E.]]
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[[Category: Hohenester E]]
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[[Category: Javaherian, K.]]
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[[Category: Javaherian K]]
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[[Category: Lanciotti, J.]]
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[[Category: Lanciotti J]]
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[[Category: Li, Y.]]
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[[Category: Li Y]]
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[[Category: Lo, K.M.]]
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[[Category: Lo K-M]]
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[[Category: Shapiro, R.]]
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[[Category: Shapiro R]]
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[[Category: Timpl, R.]]
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[[Category: Timpl R]]
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[[Category: Wiley, D.C.]]
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[[Category: Wiley DC]]
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[[Category: ZN]]
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[[Category: angiogenic]]
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[[Category: angiogenisis]]
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[[Category: antiangiogenic]]
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[[Category: cancer]]
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[[Category: collagen]]
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[[Category: collagen xviii]]
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[[Category: endostatin]]
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[[Category: extracellular matrix]]
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[[Category: zinc]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 16:12:30 2007''
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Current revision

ZINC DEPENDENT DIMERS OBSERVED IN CRYSTALS OF HUMAN ENDOSTATIN

PDB ID 1bnl

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