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1bo0

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(New page: 200px<br /> <applet load="1bo0" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bo0" /> '''MONOCYTE CHEMOATTRACTANT PROTEIN-3, NMR, MI...)
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[[Image:1bo0.gif|left|200px]]<br />
 
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<applet load="1bo0" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1bo0" />
 
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'''MONOCYTE CHEMOATTRACTANT PROTEIN-3, NMR, MINIMIZED AVERAGE STRUCTURE'''<br />
 
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==Overview==
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==MONOCYTE CHEMOATTRACTANT PROTEIN-3, NMR, MINIMIZED AVERAGE STRUCTURE==
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1H-NMR spectroscopy and analytical ultracentrifugation studies reveal that, monocyte chemoattractant protein-3 (MCP-3) is a monomer. NMR solution, structure shows that MCP-3 adopts an alphabeta fold similar to what is, observed in structures of other known chemokines. However, MCP-3 is unique, in that it does not show a propensity to form dimers. The closely related, chemokines MCP-1 and MCP-2 show a monomer-dimer equilibrium in, sedimentation equilibrium studies (approximately 0.2-2 mg/ml). As these, proteins are present at nanomolar concentrations in vivo, the results, suggest that they are monomeric at functional concentrations and that the, monomer is the functionally significant form of MCP-1, MCP-2 and MCP-3.
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<StructureSection load='1bo0' size='340' side='right'caption='[[1bo0]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1bo0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BO0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BO0 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bo0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bo0 OCA], [https://pdbe.org/1bo0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bo0 RCSB], [https://www.ebi.ac.uk/pdbsum/1bo0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bo0 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CCL7_HUMAN CCL7_HUMAN] Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor activity. Also induces the release of gelatinase B. This protein can bind heparin. Binds to CCR1, CCR2 and CCR3.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bo/1bo0_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bo0 ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1BO0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BO0 OCA].
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*[[Monocyte chemoattractant protein|Monocyte chemoattractant protein]]
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__TOC__
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==Reference==
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</StructureSection>
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Structural characterization of a monomeric chemokine: monocyte chemoattractant protein-3., Kim KS, Rajarathnam K, Clark-Lewis I, Sykes BD, FEBS Lett. 1996 Oct 21;395(2-3):277-82. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8898111 8898111]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Kim, K.S.]]
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[[Category: Kim K-S]]
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[[Category: Kwon, D.]]
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[[Category: Kwon D]]
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[[Category: Lee, D.]]
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[[Category: Lee D]]
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[[Category: Sykes, B.D.]]
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[[Category: Sykes BD]]
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[[Category: chemotactic cytokine]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 16:12:54 2007''
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Current revision

MONOCYTE CHEMOATTRACTANT PROTEIN-3, NMR, MINIMIZED AVERAGE STRUCTURE

PDB ID 1bo0

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