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1boe

From Proteopedia

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{{Seed}}
 
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[[Image:1boe.png|left|200px]]
 
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==STRUCTURE OF THE IGF BINDING DOMAIN OF THE INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN-5 (IGFBP-5): IMPLICATIONS FOR IGF AND IGF-I RECEPTOR INTERACTIONS==
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The line below this paragraph, containing "STRUCTURE_1boe", creates the "Structure Box" on the page.
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<StructureSection load='1boe' size='340' side='right'caption='[[1boe]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1boe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BOE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BOE FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1boe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1boe OCA], [https://pdbe.org/1boe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1boe RCSB], [https://www.ebi.ac.uk/pdbsum/1boe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1boe ProSAT]</span></td></tr>
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{{STRUCTURE_1boe| PDB=1boe | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IBP5_HUMAN IBP5_HUMAN] IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bo/1boe_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1boe ConSurf].
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<div style="clear:both"></div>
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===STRUCTURE OF THE IGF BINDING DOMAIN OF THE INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN-5 (IGFBP-5): IMPLICATIONS FOR IGF AND IGF-I RECEPTOR INTERACTIONS===
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==See Also==
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*[[Insulin-like growth factor binding protein 3D structures|Insulin-like growth factor binding protein 3D structures]]
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__TOC__
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<!--
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_9822601}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9822601 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9822601}}
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==About this Structure==
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1BOE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BOE OCA].
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==Reference==
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Structure of the IGF-binding domain of the insulin-like growth factor-binding protein-5 (IGFBP-5): implications for IGF and IGF-I receptor interactions., Kalus W, Zweckstetter M, Renner C, Sanchez Y, Georgescu J, Grol M, Demuth D, Schumacher R, Dony C, Lang K, Holak TA, EMBO J. 1998 Nov 16;17(22):6558-72. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9822601 9822601]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Demuth, D.]]
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[[Category: Demuth D]]
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[[Category: Georgescu, J.]]
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[[Category: Georgescu J]]
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[[Category: Grol, M.]]
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[[Category: Grol M]]
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[[Category: Holak, T H.]]
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[[Category: Holak TH]]
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[[Category: Kalus, W.]]
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[[Category: Kalus W]]
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[[Category: Lang, K.]]
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[[Category: Lang K]]
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[[Category: Renner, C.]]
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[[Category: Renner C]]
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[[Category: Sanchez, Y.]]
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[[Category: Sanchez Y]]
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[[Category: Schumacherdony, C.]]
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[[Category: Schumacherdony C]]
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[[Category: Zweckstetter, M.]]
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[[Category: Zweckstetter M]]
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[[Category: Igf]]
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[[Category: Igfbp-5]]
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[[Category: Insulin-like growth factor binding protein]]
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[[Category: Mini-igfbp-5]]
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[[Category: Nmr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:27:21 2008''
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Current revision

STRUCTURE OF THE IGF BINDING DOMAIN OF THE INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN-5 (IGFBP-5): IMPLICATIONS FOR IGF AND IGF-I RECEPTOR INTERACTIONS

PDB ID 1boe

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