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1bqt

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{{STRUCTURE_1bqt| PDB=1bqt | SCENE= }}
 
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===THREE-DIMENSIONAL STRUCTURE OF HUMAN INSULIN-LIKE GROWTH FACTOR-I (IGF-I) DETERMINED BY 1H-NMR AND DISTANCE GEOMETRY, 6 STRUCTURES===
 
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{{ABSTRACT_PUBMED_8391516}}
 
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==Disease==
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==THREE-DIMENSIONAL STRUCTURE OF HUMAN INSULIN-LIKE GROWTH FACTOR-I (IGF-I) DETERMINED BY 1H-NMR AND DISTANCE GEOMETRY, 6 STRUCTURES==
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[[http://www.uniprot.org/uniprot/IGF1_HUMAN IGF1_HUMAN]] Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:[http://omim.org/entry/608747 608747]]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.
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<StructureSection load='1bqt' size='340' side='right'caption='[[1bqt]]' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[1bqt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BQT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BQT FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/IGF1_HUMAN IGF1_HUMAN]] The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake.<ref>PMID:21076856</ref>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bqt OCA], [https://pdbe.org/1bqt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bqt RCSB], [https://www.ebi.ac.uk/pdbsum/1bqt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bqt ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[1bqt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BQT OCA].
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== Disease ==
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[https://www.uniprot.org/uniprot/IGF1_HUMAN IGF1_HUMAN] Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:[https://omim.org/entry/608747 608747]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.
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== Function ==
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[https://www.uniprot.org/uniprot/IGF1_HUMAN IGF1_HUMAN] The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake.<ref>PMID:21076856</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bq/1bqt_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bqt ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
*[[Insulin-like growth factor|Insulin-like growth factor]]
*[[Insulin-like growth factor|Insulin-like growth factor]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:008391516</ref><references group="xtra"/><references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Kobayashi, M.]]
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[[Category: Large Structures]]
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[[Category: Kobayashi, Y.]]
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[[Category: Kobayashi M]]
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[[Category: Koyama, S.]]
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[[Category: Kobayashi Y]]
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[[Category: Kyogoku, Y.]]
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[[Category: Koyama S]]
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[[Category: Nishimura, S.]]
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[[Category: Kyogoku Y]]
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[[Category: Ohkubo, T.]]
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[[Category: Nishimura S]]
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[[Category: Sato, A.]]
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[[Category: Ohkubo T]]
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[[Category: Yasuda, T.]]
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[[Category: Sato A]]
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[[Category: Growth factor]]
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[[Category: Yasuda T]]
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[[Category: Insulin]]
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Current revision

THREE-DIMENSIONAL STRUCTURE OF HUMAN INSULIN-LIKE GROWTH FACTOR-I (IGF-I) DETERMINED BY 1H-NMR AND DISTANCE GEOMETRY, 6 STRUCTURES

PDB ID 1bqt

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