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1bv8

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{{Seed}}
 
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[[Image:1bv8.png|left|200px]]
 
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==RECEPTOR DOMAIN FROM ALPHA-2-MACROGLOBULIN==
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The line below this paragraph, containing "STRUCTURE_1bv8", creates the "Structure Box" on the page.
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<StructureSection load='1bv8' size='340' side='right'caption='[[1bv8]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1bv8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BV8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BV8 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bv8 OCA], [https://pdbe.org/1bv8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bv8 RCSB], [https://www.ebi.ac.uk/pdbsum/1bv8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bv8 ProSAT]</span></td></tr>
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{{STRUCTURE_1bv8| PDB=1bv8 | SCENE= }}
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</table>
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== Function ==
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===RECEPTOR DOMAIN FROM ALPHA-2-MACROGLOBULIN===
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[https://www.uniprot.org/uniprot/A2MG_HUMAN A2MG_HUMAN] Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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The line below this paragraph, {{ABSTRACT_PUBMED_10318830}}, adds the Publication Abstract to the page
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 10318830 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bv/1bv8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_10318830}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bv8 ConSurf].
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1BV8 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BV8 OCA].
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<div style="clear:both"></div>
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:10318830</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Dolmer, K.]]
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[[Category: Large Structures]]
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[[Category: Gettins, P G.W.]]
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[[Category: Dolmer K]]
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[[Category: Huang, W.]]
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[[Category: Gettins PGW]]
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[[Category: Liao, X.]]
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[[Category: Huang W]]
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[[Category: Proteinase]]
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[[Category: Liao X]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 11:43:38 2009''
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Current revision

RECEPTOR DOMAIN FROM ALPHA-2-MACROGLOBULIN

PDB ID 1bv8

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