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1bxt

From Proteopedia

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[[Image:1bxt.gif|left|200px]]
 
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{{Structure
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==STREPTOCOCCAL SUPERANTIGEN (SSA) FROM STREPTOCOCCUS PYOGENES==
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|PDB= 1bxt |SIZE=350|CAPTION= <scene name='initialview01'>1bxt</scene>, resolution 1.85&Aring;
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<StructureSection load='1bxt' size='340' side='right'caption='[[1bxt]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1bxt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BXT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BXT FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bxt OCA], [https://pdbe.org/1bxt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bxt RCSB], [https://www.ebi.ac.uk/pdbsum/1bxt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bxt ProSAT]</span></td></tr>
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|DOMAIN=
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</table>
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|RELATEDENTRY=
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== Function ==
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bxt OCA], [http://www.ebi.ac.uk/pdbsum/1bxt PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1bxt RCSB]</span>
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[https://www.uniprot.org/uniprot/Q54971_STRPY Q54971_STRPY]
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}}
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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'''STREPTOCOCCAL SUPERANTIGEN (SSA) FROM STREPTOCOCCUS PYOGENES'''
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bx/1bxt_consurf.spt"</scriptWhenChecked>
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==Overview==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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Streptococcal superantigen (SSA) is a 28,000 Mr toxin originally isolated from a pathogenic strain of Streptococcus pyogenes that has 60% sequence identity with staphylococcal enterotoxin B (SEB). SSA and SEB, however, do not compete for binding on the surfaces of cells expressing MHC class II molecules. This behavior had been ascribed to SSA and SEB binding to distinct sites on, or different subsets of, HLA-DR molecules. Here we demonstrate that SSA binds predominantly to HLA-DQ, rather than to HLA-DR molecules, and present the crystal structure of SSA at 1.85 A resolution. These data provide a structural basis for interpreting the interaction of SSA with HLA-DQ molecules as well as a foundation for understanding bacterial superantigen affinities for distinct MHC isotypes.
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bxt ConSurf].
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1BXT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BXT OCA].
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<div style="clear:both"></div>
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__TOC__
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==Reference==
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</StructureSection>
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Structural basis for HLA-DQ binding by the streptococcal superantigen SSA., Sundberg E, Jardetzky TS, Nat Struct Biol. 1999 Feb;6(2):123-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10048922 10048922]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Streptococcus pyogenes]]
[[Category: Streptococcus pyogenes]]
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[[Category: Jardetzky, T.]]
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[[Category: Jardetzky T]]
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[[Category: Sundberg, E.]]
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[[Category: Sundberg E]]
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[[Category: bacterial superantigen]]
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[[Category: mhc class ii interaction]]
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[[Category: t cell activation]]
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[[Category: toxic shock-like syndrome]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:10:28 2008''
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Current revision

STREPTOCOCCAL SUPERANTIGEN (SSA) FROM STREPTOCOCCUS PYOGENES

PDB ID 1bxt

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