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1c1j

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<StructureSection load='1c1j' size='340' side='right'caption='[[1c1j]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
<StructureSection load='1c1j' size='340' side='right'caption='[[1c1j]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1c1j]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Gloydius_halys Gloydius halys]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C1J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1C1J FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1c1j]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Gloydius_halys Gloydius halys]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C1J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1C1J FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1jia|1jia]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1c1j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c1j OCA], [https://pdbe.org/1c1j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1c1j RCSB], [https://www.ebi.ac.uk/pdbsum/1c1j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1c1j ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c1j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c1j OCA], [http://pdbe.org/1c1j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1c1j RCSB], [http://www.ebi.ac.uk/pdbsum/1c1j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1c1j ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PA2BB_GLOHA PA2BB_GLOHA] Snake venom phospholipase A2 (PLA2) that shows potent hemolytic activity, and exhibits medium anticoagulant effects by binding to factor Xa (F10) and inhibiting the prothrombinase activity (IC(50) is 90 nM). It is one of the few phospholipases A2 capable of hydrolyzing the phospholipids of E.coli membranes in the presence of a bactericidal/permeability-increasing protein (BPI) of neutrophils. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.<ref>PMID:18062812</ref> <ref>PMID:10728829</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
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*[[Phospholipase A2|Phospholipase A2]]
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*[[Phospholipase A2 3D structures|Phospholipase A2 3D structures]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Gloydius halys]]
[[Category: Gloydius halys]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lin, Z j]]
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[[Category: Lin Z-j]]
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[[Category: Song, S y]]
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[[Category: Song S-y]]
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[[Category: Zhang, H l]]
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[[Category: Zhang H-l]]
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[[Category: Zhang, Y q]]
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[[Category: Zhang Y-q]]
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[[Category: Zhou, Y]]
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[[Category: Zhou Y]]
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[[Category: Cadmium]]
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[[Category: Catalytic mechanism]]
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[[Category: Hydrolase]]
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[[Category: Phospholipase a2]]
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[[Category: Venom]]
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Current revision

STRUCTURE OF CADMIUM-SUBSTITUTED PHOSPHOLIPASE A2 FROM AGKISTRONDON HALYS PALLAS AT 2.8 ANGSTROMS RESOLUTION

PDB ID 1c1j

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