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1cb2

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{{Seed}}
 
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[[Image:1cb2.png|left|200px]]
 
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==CELLOBIOHYDROLASE II, CATALYTIC DOMAIN, MUTANT Y169F==
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The line below this paragraph, containing "STRUCTURE_1cb2", creates the "Structure Box" on the page.
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<StructureSection load='1cb2' size='340' side='right'caption='[[1cb2]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1cb2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trichoderma_reesei Trichoderma reesei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CB2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CB2 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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{{STRUCTURE_1cb2| PDB=1cb2 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cb2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cb2 OCA], [https://pdbe.org/1cb2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cb2 RCSB], [https://www.ebi.ac.uk/pdbsum/1cb2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cb2 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GUX2_HYPJE GUX2_HYPJE] The biological conversion of cellulose to glucose generally requires three types of hydrolytic enzymes: (1) Endoglucanases which cut internal beta-1,4-glucosidic bonds; (2) Exocellobiohydrolases that cut the dissaccharide cellobiose from the non-reducing end of the cellulose polymer chain; (3) Beta-1,4-glucosidases which hydrolyze the cellobiose and other short cello-oligosaccharides to glucose.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cb/1cb2_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1cb2 ConSurf].
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<div style="clear:both"></div>
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===CELLOBIOHYDROLASE II, CATALYTIC DOMAIN, MUTANT Y169F===
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==See Also==
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*[[Cellobiohydrolase 3D structures|Cellobiohydrolase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_8875646}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 8875646 is the PubMed ID number.
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[[Category: Trichoderma reesei]]
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[[Category: Jones TA]]
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{{ABSTRACT_PUBMED_8875646}}
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[[Category: Kleywegt GJ]]
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[[Category: Szardenings M]]
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==About this Structure==
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1CB2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Hypocrea_jecorina Hypocrea jecorina]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CB2 OCA].
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==Reference==
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The active site of Trichoderma reesei cellobiohydrolase II: the role of tyrosine 169., Koivula A, Reinikainen T, Ruohonen L, Valkeajarvi A, Claeyssens M, Teleman O, Kleywegt GJ, Szardenings M, Rouvinen J, Jones TA, Teeri TT, Protein Eng. 1996 Aug;9(8):691-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8875646 8875646]
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[[Category: Cellulose 1,4-beta-cellobiosidase]]
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[[Category: Hypocrea jecorina]]
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[[Category: Single protein]]
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[[Category: Jones, T A.]]
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[[Category: Kleywegt, G J.]]
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[[Category: Szardenings, M.]]
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[[Category: Glycoprotein]]
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[[Category: Glycosidase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:29:46 2008''
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Current revision

CELLOBIOHYDROLASE II, CATALYTIC DOMAIN, MUTANT Y169F

PDB ID 1cb2

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