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1cgj

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{{STRUCTURE_1cgj| PDB=1cgj | SCENE= }}
 
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===THREE-DIMENSIONAL STRUCTURE OF THE COMPLEXES BETWEEN BOVINE CHYMOTRYPSINOGEN*A AND TWO RECOMBINANT VARIANTS OF HUMAN PANCREATIC SECRETORY TRYPSIN INHIBITOR (KAZAL-TYPE)===
 
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{{ABSTRACT_PUBMED_1870127}}
 
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==Disease==
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==THREE-DIMENSIONAL STRUCTURE OF THE COMPLEXES BETWEEN BOVINE CHYMOTRYPSINOGEN*A AND TWO RECOMBINANT VARIANTS OF HUMAN PANCREATIC SECRETORY TRYPSIN INHIBITOR (KAZAL-TYPE)==
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[[http://www.uniprot.org/uniprot/ISK1_HUMAN ISK1_HUMAN]] Defects in SPINK1 are a cause of pancreatitis (PCTT) [MIM:[http://omim.org/entry/167800 167800]]. A disease characterized by the presence of calculi in pancreatic ducts. It causes severe abdominal pain attacks.<ref>PMID:10835640</ref><ref>PMID:10691414</ref><ref>PMID:12974284</ref> Defects in SPINK1 are the cause of susceptibility to tropical calcific pancreatitis (TCP) [MIM:[http://omim.org/entry/608189 608189]]. TCP is an idiopathic, juvenile, nonalcoholic form of chronic pancreatitis widely prevalent in several tropical countries. It can be associated with fibrocalculous pancreatic diabetes (FCPD) depending on both environmental and genetic factors. TCP differs from alcoholic pancreatitis by a much younger age of onset, pancreatic calcification, a high incidence of insulin dependent but ketosis resistant diabetes mellitus, and an exceptionally high incidence of pancreatic cancer.<ref>PMID:12187509</ref><ref>PMID:12011155</ref>
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<StructureSection load='1cgj' size='340' side='right'caption='[[1cgj]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1cgj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CGJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CGJ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cgj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cgj OCA], [https://pdbe.org/1cgj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cgj RCSB], [https://www.ebi.ac.uk/pdbsum/1cgj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cgj ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CTRA_BOVIN CTRA_BOVIN]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cg/1cgj_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1cgj ConSurf].
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<div style="clear:both"></div>
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==Function==
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==See Also==
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[[http://www.uniprot.org/uniprot/ISK1_HUMAN ISK1_HUMAN]] This is a trypsin inhibitor, its physiological function is to prevent the trypsin-catalyzed premature activation of zymogens within the pancreas.
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*[[Chymotrypsin 3D structures|Chymotrypsin 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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[[1cgj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CGJ OCA].
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==Reference==
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<ref group="xtra">PMID:001870127</ref><references group="xtra"/><references/>
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[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Collins, J.]]
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[[Category: Large Structures]]
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[[Category: Hecht, H J.]]
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[[Category: Collins J]]
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[[Category: Schomburg, D.]]
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[[Category: Hecht HJ]]
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[[Category: Szardenings, M.]]
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[[Category: Schomburg D]]
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[[Category: Serine protease-inhibitor complex]]
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[[Category: Szardenings M]]
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[[Category: Serine protease-inhibitor complex complex]]
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Current revision

THREE-DIMENSIONAL STRUCTURE OF THE COMPLEXES BETWEEN BOVINE CHYMOTRYPSINOGEN*A AND TWO RECOMBINANT VARIANTS OF HUMAN PANCREATIC SECRETORY TRYPSIN INHIBITOR (KAZAL-TYPE)

PDB ID 1cgj

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