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1cqi

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[[Image:1cqi.png|left|200px]]
 
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{{STRUCTURE_1cqi| PDB=1cqi | SCENE= }}
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==Crystal Structure of the Complex of ADP and MG2+ with Dephosphorylated E. Coli Succinyl-CoA Synthetase==
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<StructureSection load='1cqi' size='340' side='right'caption='[[1cqi]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
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===Crystal Structure of the Complex of ADP and MG2+ with Dephosphorylated E. Coli Succinyl-CoA Synthetase===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1cqi]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. The October 2012 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Citric Acid Cycle'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2012_10 10.2210/rcsb_pdb/mom_2012_10]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CQI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CQI FirstGlance]. <br>
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{{ABSTRACT_PUBMED_10625475}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cqi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cqi OCA], [https://pdbe.org/1cqi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cqi RCSB], [https://www.ebi.ac.uk/pdbsum/1cqi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cqi ProSAT]</span></td></tr>
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[[1cqi]] is a 4 chain structure of [[Succinyl-CoA synthetase]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CQI OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SUCD_ECOLI SUCD_ECOLI] During aerobic metabolism it functions in the citric acid cycle, coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents an important site of substrate-level phosphorylation. It can also function in the other direction for anabolic purposes, and this may be particularly important for providing succinyl-CoA during anaerobic growth when the oxidative route from 2-oxoglutarate is severely repressed. The alpha-subunit binds CoA, as well as ATP and catalyzes phosphoryl transfer to one of its histidine residues. The complete active site is probably located in the region of alpha-beta contact.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cq/1cqi_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1cqi ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Succinyl-CoA synthetase|Succinyl-CoA synthetase]]
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*[[Succinyl-CoA synthetase 3D structures|Succinyl-CoA synthetase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:010625475</ref><references group="xtra"/>
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[[Category: Citric Acid Cycle]]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Bridger, W A.]]
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[[Category: Large Structures]]
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[[Category: Fraser, M E.]]
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[[Category: RCSB PDB Molecule of the Month]]
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[[Category: James, M N.G.]]
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[[Category: Bridger WA]]
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[[Category: Joyce, M A.]]
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[[Category: Fraser ME]]
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[[Category: Wolodko, W T.]]
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[[Category: James MNG]]
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[[Category: Atp-grasp fold]]
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[[Category: Joyce MA]]
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[[Category: Ligase]]
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[[Category: Wolodko WT]]
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[[Category: Rossmann fold]]
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Current revision

Crystal Structure of the Complex of ADP and MG2+ with Dephosphorylated E. Coli Succinyl-CoA Synthetase

PDB ID 1cqi

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