1cre

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "1cre" [edit=sysop:move=sysop])
Current revision (15:42, 13 March 2024) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1cre.png|left|200px]]
 
-
<!--
+
==CARDIOTOXIN II FROM TAIWAN COBRA VENOM, NAJA NAJA ATRA: STRUCTURE IN SOLUTION AND COMPARISION AMONG HOMOLOGOUS CARDIOTOXINS==
-
The line below this paragraph, containing "STRUCTURE_1cre", creates the "Structure Box" on the page.
+
<StructureSection load='1cre' size='340' side='right'caption='[[1cre]]' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1cre]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CRE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CRE FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cre FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cre OCA], [https://pdbe.org/1cre PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cre RCSB], [https://www.ebi.ac.uk/pdbsum/1cre PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cre ProSAT]</span></td></tr>
-
{{STRUCTURE_1cre| PDB=1cre | SCENE= }}
+
</table>
-
 
+
== Function ==
-
===CARDIOTOXIN II FROM TAIWAN COBRA VENOM, NAJA NAJA ATRA: STRUCTURE IN SOLUTION AND COMPARISION AMONG HOMOLOGOUS CARDIOTOXINS===
+
[https://www.uniprot.org/uniprot/3SA2_NAJAT 3SA2_NAJAT] Basic protein that binds to cell membrane and depolarizes cardiomyocytes. It also shows lytic activities, but 2-fold less important than that of CTX-A4. It binds to the integrin alpha-V/beta-3 (ITGAV/ITGB3) with a moderate affinity. It may interact with sulfatides in the cell membrane which induces pore formation and cell internalization and is responsible for cytotoxicity in cardiomyocytes. It also may target the mitochondrial membrane and induce mitochondrial swelling and fragmentation.<ref>PMID:9398182</ref>
-
 
+
== Evolutionary Conservation ==
-
 
+
[[Image:Consurf_key_small.gif|200px|right]]
-
<!--
+
Check<jmol>
-
The line below this paragraph, {{ABSTRACT_PUBMED_8089116}}, adds the Publication Abstract to the page
+
<jmolCheckbox>
-
(as it appears on PubMed at http://www.pubmed.gov), where 8089116 is the PubMed ID number.
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cr/1cre_consurf.spt"</scriptWhenChecked>
-
-->
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
{{ABSTRACT_PUBMED_8089116}}
+
<text>to colour the structure by Evolutionary Conservation</text>
-
 
+
</jmolCheckbox>
-
==About this Structure==
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1cre ConSurf].
-
[[1cre]] is a 1 chain structure of [[Cardiotoxin]] with sequence from [http://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CRE OCA].
+
<div style="clear:both"></div>
==See Also==
==See Also==
-
*[[Cardiotoxin]]
+
*[[Cardiotoxin 3D structures|Cardiotoxin 3D structures]]
-
 
+
== References ==
-
==Reference==
+
<references/>
-
<ref group="xtra">PMID:8089116</ref><references group="xtra"/>
+
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
[[Category: Naja atra]]
[[Category: Naja atra]]
-
[[Category: Bhaskaran, R.]]
+
[[Category: Bhaskaran R]]
-
[[Category: Chang, K D.]]
+
[[Category: Chang KD]]
-
[[Category: Huang, C C.]]
+
[[Category: Huang CC]]
-
[[Category: Yu, C.]]
+
[[Category: Yu C]]
-
[[Category: Cardiotoxin]]
+

Current revision

CARDIOTOXIN II FROM TAIWAN COBRA VENOM, NAJA NAJA ATRA: STRUCTURE IN SOLUTION AND COMPARISION AMONG HOMOLOGOUS CARDIOTOXINS

PDB ID 1cre

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1cre"
Personal tools