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1crf

From Proteopedia

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{{Seed}}
 
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[[Image:1crf.png|left|200px]]
 
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==CARDIOTOXIN II FROM TAIWAN COBRA VENOM, NAJA NAJA ATRA: STRUCTURE IN SOLUTION AND COMPARISION AMONG HOMOLOGOUS CARDIOTOXINS==
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The line below this paragraph, containing "STRUCTURE_1crf", creates the "Structure Box" on the page.
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<StructureSection load='1crf' size='340' side='right'caption='[[1crf]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1crf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CRF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CRF FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1crf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1crf OCA], [https://pdbe.org/1crf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1crf RCSB], [https://www.ebi.ac.uk/pdbsum/1crf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1crf ProSAT]</span></td></tr>
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{{STRUCTURE_1crf| PDB=1crf | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/3SA2_NAJAT 3SA2_NAJAT] Basic protein that binds to cell membrane and depolarizes cardiomyocytes. It also shows lytic activities, but 2-fold less important than that of CTX-A4. It binds to the integrin alpha-V/beta-3 (ITGAV/ITGB3) with a moderate affinity. It may interact with sulfatides in the cell membrane which induces pore formation and cell internalization and is responsible for cytotoxicity in cardiomyocytes. It also may target the mitochondrial membrane and induce mitochondrial swelling and fragmentation.<ref>PMID:9398182</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cr/1crf_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1crf ConSurf].
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<div style="clear:both"></div>
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===CARDIOTOXIN II FROM TAIWAN COBRA VENOM, NAJA NAJA ATRA: STRUCTURE IN SOLUTION AND COMPARISION AMONG HOMOLOGOUS CARDIOTOXINS===
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==See Also==
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*[[Cardiotoxin 3D structures|Cardiotoxin 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_8089116}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 8089116 is the PubMed ID number.
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</StructureSection>
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_8089116}}
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==About this Structure==
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1CRF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CRF OCA].
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==Reference==
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Cardiotoxin II from Taiwan cobra venom, Naja naja atra. Structure in solution and comparison among homologous cardiotoxins., Bhaskaran R, Huang CC, Tsai YC, Jayaraman G, Chang DK, Yu C, J Biol Chem. 1994 Sep 23;269(38):23500-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8089116 8089116]
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[[Category: Naja atra]]
[[Category: Naja atra]]
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[[Category: Single protein]]
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[[Category: Bhaskaran R]]
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[[Category: Bhaskaran, R.]]
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[[Category: Chang KD]]
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[[Category: Chang, K D.]]
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[[Category: Huang CC]]
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[[Category: Huang, C C.]]
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[[Category: Yu C]]
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[[Category: Yu, C.]]
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[[Category: Cardiotoxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 21:13:08 2008''
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Current revision

CARDIOTOXIN II FROM TAIWAN COBRA VENOM, NAJA NAJA ATRA: STRUCTURE IN SOLUTION AND COMPARISION AMONG HOMOLOGOUS CARDIOTOXINS

PDB ID 1crf

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