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1cs6

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[[Image:1cs6.gif|left|200px]]
 
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{{Structure
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==N-TERMINAL FRAGMENT OF AXONIN-1 FROM CHICKEN==
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|PDB= 1cs6 |SIZE=350|CAPTION= <scene name='initialview01'>1cs6</scene>, resolution 1.80&Aring;
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<StructureSection load='1cs6' size='340' side='right'caption='[[1cs6]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
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<table><tr><td colspan='2'>[[1cs6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CS6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CS6 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cs6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cs6 OCA], [https://pdbe.org/1cs6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cs6 RCSB], [https://www.ebi.ac.uk/pdbsum/1cs6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cs6 ProSAT]</span></td></tr>
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</table>
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'''N-TERMINAL FRAGMENT OF AXONIN-1 FROM CHICKEN'''
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== Function ==
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[https://www.uniprot.org/uniprot/CNTN2_CHICK CNTN2_CHICK] Axon-associated cell adhesion molecule (AxCAM) which promotes neurite outgrowth by interaction with the AxCAM L1 (G4) of neuritic membrane.
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== Evolutionary Conservation ==
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==Overview==
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[[Image:Consurf_key_small.gif|200px|right]]
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We have determined the crystal structure of the ligand binding fragment of the neural cell adhesion molecule axonin-1/TAG-1 comprising the first four immunoglobulin (Ig) domains. The overall structure of axonin-1(Ig1-4) is U-shaped due to contacts between domains 1 and 4 and domains 2 and 3. In the crystals, these molecules are aligned in a string with adjacent molecules oriented in an anti-parallel fashion and their C termini perpendicular to the string. This arrangement suggests that cell adhesion by homophilic axonin-1 interaction occurs by the formation of a linear zipper-like array in which the axonin-1 molecules are alternately provided by the two apposed membranes. In accordance with this model, mutations in a loop critical for the formation of the zipper resulted in the loss of the homophilic binding capacity of axonin-1.
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cs/1cs6_consurf.spt"</scriptWhenChecked>
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1CS6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CS6 OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==Reference==
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</jmolCheckbox>
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The crystal structure of the ligand binding module of axonin-1/TAG-1 suggests a zipper mechanism for neural cell adhesion., Freigang J, Proba K, Leder L, Diederichs K, Sonderegger P, Welte W, Cell. 2000 May 12;101(4):425-33. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10830169 10830169]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1cs6 ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Diederichs, K.]]
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[[Category: Diederichs K]]
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[[Category: Freigang, J.]]
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[[Category: Freigang J]]
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[[Category: Proba, K.]]
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[[Category: Proba K]]
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[[Category: Sonderegger, P.]]
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[[Category: Sonderegger P]]
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[[Category: Welte, W.]]
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[[Category: Welte W]]
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[[Category: GOL]]
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[[Category: neural cell adhesion]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:28:15 2008''
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Current revision

N-TERMINAL FRAGMENT OF AXONIN-1 FROM CHICKEN

PDB ID 1cs6

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