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1cxn
From Proteopedia
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| - | [[Image:1cxn.png|left|200px]] | ||
| - | + | ==REFINED THREE-DIMENSIONAL SOLUTION STRUCTURE OF A SNAKE CARDIOTOXIN: ANALYSIS OF THE SIDE-CHAIN ORGANISATION SUGGESTS THE EXISTENCE OF A POSSIBLE PHOSPHOLIPID BINDING SITE== | |
| - | + | <StructureSection load='1cxn' size='340' side='right'caption='[[1cxn]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1cxn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Naja_nigricollis Naja nigricollis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CXN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CXN FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cxn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cxn OCA], [https://pdbe.org/1cxn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cxn RCSB], [https://www.ebi.ac.uk/pdbsum/1cxn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cxn ProSAT]</span></td></tr> | |
| - | == | + | </table> |
| - | [[1cxn]] is a 1 chain structure with sequence from [ | + | == Function == |
| + | [https://www.uniprot.org/uniprot/3SA1_NAJPA 3SA1_NAJPA] Basic protein that binds to cell membrane and depolarizes cardiomyocytes. This cytotoxin also possesses lytic activity on many other cells, including red blood cells. Interaction with sulfatides in the cell membrane induces pore formation and cell internalization and is responsible for cytotoxicity in cardiomyocytes. It targets the mitochondrial membrane and induces mitochondrial swelling and fragmentation. Inhibits protein kinases C. It binds to the integrin alpha-V/beta-3 with a moderate affinity.[UniProtKB:P01443] | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cx/1cxn_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1cxn ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Cardiotoxin|Cardiotoxin]] | + | *[[Cardiotoxin 3D structures|Cardiotoxin 3D structures]] |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | < | + | [[Category: Large Structures]] |
[[Category: Naja nigricollis]] | [[Category: Naja nigricollis]] | ||
| - | [[Category: Gilquin | + | [[Category: Gilquin B]] |
| - | [[Category: Menez | + | [[Category: Menez A]] |
| - | [[Category: Roumestand | + | [[Category: Roumestand C]] |
| - | [[Category: Toma | + | [[Category: Toma F]] |
| - | [[Category: Zinn-Justin | + | [[Category: Zinn-Justin S]] |
| - | + | ||
Current revision
REFINED THREE-DIMENSIONAL SOLUTION STRUCTURE OF A SNAKE CARDIOTOXIN: ANALYSIS OF THE SIDE-CHAIN ORGANISATION SUGGESTS THE EXISTENCE OF A POSSIBLE PHOSPHOLIPID BINDING SITE
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