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1cxo

From Proteopedia

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{{Seed}}
 
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[[Image:1cxo.png|left|200px]]
 
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==REFINED THREE-DIMENSIONAL SOLUTION STRUCTURE OF A SNAKE CARDIOTOXIN: ANALYSIS OF THE SIDE-CHAIN ORGANISATION SUGGESTS THE EXISTENCE OF A POSSIBLE PHOSPHOLIPID BINDING SITE==
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The line below this paragraph, containing "STRUCTURE_1cxo", creates the "Structure Box" on the page.
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<StructureSection load='1cxo' size='340' side='right'caption='[[1cxo]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1cxo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Naja_nigricollis Naja nigricollis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CXO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CXO FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cxo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cxo OCA], [https://pdbe.org/1cxo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cxo RCSB], [https://www.ebi.ac.uk/pdbsum/1cxo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cxo ProSAT]</span></td></tr>
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{{STRUCTURE_1cxo| PDB=1cxo | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/3SA1_NAJPA 3SA1_NAJPA] Basic protein that binds to cell membrane and depolarizes cardiomyocytes. This cytotoxin also possesses lytic activity on many other cells, including red blood cells. Interaction with sulfatides in the cell membrane induces pore formation and cell internalization and is responsible for cytotoxicity in cardiomyocytes. It targets the mitochondrial membrane and induces mitochondrial swelling and fragmentation. Inhibits protein kinases C. It binds to the integrin alpha-V/beta-3 with a moderate affinity.[UniProtKB:P01443]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cx/1cxo_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1cxo ConSurf].
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<div style="clear:both"></div>
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===REFINED THREE-DIMENSIONAL SOLUTION STRUCTURE OF A SNAKE CARDIOTOXIN: ANALYSIS OF THE SIDE-CHAIN ORGANISATION SUGGESTS THE EXISTENCE OF A POSSIBLE PHOSPHOLIPID BINDING SITE===
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==See Also==
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*[[Cardiotoxin 3D structures|Cardiotoxin 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_8241426}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 8241426 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8241426}}
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==About this Structure==
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1CXO is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Naja_nigricollis Naja nigricollis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CXO OCA].
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==Reference==
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<ref group="xtra">PMID:8241426</ref><references group="xtra"/>
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[[Category: Naja nigricollis]]
[[Category: Naja nigricollis]]
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[[Category: Gilquin, B.]]
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[[Category: Gilquin B]]
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[[Category: Menez, A.]]
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[[Category: Menez A]]
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[[Category: Roumestand, C.]]
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[[Category: Roumestand C]]
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[[Category: Toma, F.]]
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[[Category: Toma F]]
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[[Category: Zinn-Justin, S.]]
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[[Category: Zinn-Justin S]]
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[[Category: Cytotoxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 19:55:15 2009''
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Current revision

REFINED THREE-DIMENSIONAL SOLUTION STRUCTURE OF A SNAKE CARDIOTOXIN: ANALYSIS OF THE SIDE-CHAIN ORGANISATION SUGGESTS THE EXISTENCE OF A POSSIBLE PHOSPHOLIPID BINDING SITE

PDB ID 1cxo

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