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1cz8

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[[Image:1cz8.png|left|200px]]
 
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{{STRUCTURE_1cz8| PDB=1cz8 | SCENE= }}
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==VASCULAR ENDOTHELIAL GROWTH FACTOR IN COMPLEX WITH AN AFFINITY MATURED ANTIBODY==
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<StructureSection load='1cz8' size='340' side='right'caption='[[1cz8]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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===VASCULAR ENDOTHELIAL GROWTH FACTOR IN COMPLEX WITH AN AFFINITY MATURED ANTIBODY===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1cz8]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CZ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CZ8 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_10543973}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cz8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cz8 OCA], [https://pdbe.org/1cz8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cz8 RCSB], [https://www.ebi.ac.uk/pdbsum/1cz8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cz8 ProSAT]</span></td></tr>
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[[1cz8]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CZ8 OCA].
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/VEGFA_HUMAN VEGFA_HUMAN] Defects in VEGFA are a cause of susceptibility to microvascular complications of diabetes type 1 (MVCD1) [MIM:[https://omim.org/entry/603933 603933]. These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.
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== Function ==
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[https://www.uniprot.org/uniprot/VEGFA_HUMAN VEGFA_HUMAN] Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth.<ref>PMID:11427521</ref> <ref>PMID:15520188</ref> <ref>PMID:16489009</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cz/1cz8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1cz8 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Vascular Endothelial Growth Factor|Vascular Endothelial Growth Factor]]
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*[[Antibody 3D structures|Antibody 3D structures]]
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*[[VEGF 3D Structures|VEGF 3D Structures]]
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==Reference==
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*[[3D structures of human antibody|3D structures of human antibody]]
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<ref group="xtra">PMID:010543973</ref><references group="xtra"/>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Chen, Y.]]
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[[Category: Chen Y]]
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[[Category: Christinger, H W.]]
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[[Category: Christinger HW]]
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[[Category: Fuh, G.]]
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[[Category: Fuh G]]
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[[Category: Li, B.]]
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[[Category: Li B]]
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[[Category: Lowman, H B.]]
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[[Category: Lowman HB]]
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[[Category: McKay, P.]]
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[[Category: McKay P]]
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[[Category: Vos, A M.de.]]
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[[Category: Wiesmann C]]
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[[Category: Wiesmann, C.]]
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[[Category: De Vos AM]]
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[[Category: Cystine knot]]
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[[Category: Fab fragment]]
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[[Category: Immune system]]
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Current revision

VASCULAR ENDOTHELIAL GROWTH FACTOR IN COMPLEX WITH AN AFFINITY MATURED ANTIBODY

PDB ID 1cz8

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