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1czw

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==STRUCTURE OF THE W34A MUTANT OF SHIGA-LIKE TOXIN I B SUBUNIT==
==STRUCTURE OF THE W34A MUTANT OF SHIGA-LIKE TOXIN I B SUBUNIT==
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<StructureSection load='1czw' size='340' side='right' caption='[[1czw]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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<StructureSection load='1czw' size='340' side='right'caption='[[1czw]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1czw]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Bph30 Bph30]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CZW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CZW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1czw]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Phage_h30 Phage h30]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CZW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CZW FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1bos|1bos]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1czw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1czw OCA], [http://pdbe.org/1czw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1czw RCSB], [http://www.ebi.ac.uk/pdbsum/1czw PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1czw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1czw OCA], [https://pdbe.org/1czw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1czw RCSB], [https://www.ebi.ac.uk/pdbsum/1czw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1czw ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/STXB_BPH30 STXB_BPH30]] The B subunit is responsible for the binding of the holotoxin to specific receptors on the target cell surface, such as globotriaosylceramide (Gb3) in human intestinal microvilli.
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[https://www.uniprot.org/uniprot/STXB_BPH19 STXB_BPH19] The B subunit is responsible for the binding of the holotoxin to specific receptors on the target cell surface, such as globotriaosylceramide (Gb3) in human intestinal microvilli.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cz/1czw_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cz/1czw_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1czw ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Shiga toxin|Shiga toxin]]
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*[[Shiga toxin 3D structures|Shiga toxin 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bph30]]
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[[Category: Large Structures]]
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[[Category: Boodhoo, A]]
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[[Category: Phage h30]]
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[[Category: Brunton, J L]]
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[[Category: Boodhoo A]]
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[[Category: Ling, H]]
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[[Category: Brunton JL]]
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[[Category: Read, R J]]
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[[Category: Ling H]]
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[[Category: Bacterial toxin]]
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[[Category: Read RJ]]
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[[Category: Ob-fold]]
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[[Category: Protein-carbohydrate recognition]]
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[[Category: Sugar receptor binding domain]]
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[[Category: Toxin]]
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Current revision

STRUCTURE OF THE W34A MUTANT OF SHIGA-LIKE TOXIN I B SUBUNIT

PDB ID 1czw

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