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1d2q

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{{Seed}}
 
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[[Image:1d2q.png|left|200px]]
 
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==CRYSTAL STRUCTURE OF HUMAN TRAIL==
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The line below this paragraph, containing "STRUCTURE_1d2q", creates the "Structure Box" on the page.
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<StructureSection load='1d2q' size='340' side='right'caption='[[1d2q]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1d2q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D2Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1D2Q FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1d2q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d2q OCA], [https://pdbe.org/1d2q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1d2q RCSB], [https://www.ebi.ac.uk/pdbsum/1d2q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1d2q ProSAT]</span></td></tr>
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{{STRUCTURE_1d2q| PDB=1d2q | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TNF10_HUMAN TNF10_HUMAN] Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d2/1d2q_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1d2q ConSurf].
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<div style="clear:both"></div>
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===CRYSTAL STRUCTURE OF HUMAN TRAIL===
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==See Also==
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*[[TRAIL|TRAIL]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_10485660}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10485660 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10485660}}
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==About this Structure==
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1D2Q is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D2Q OCA].
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==Reference==
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2.8 A resolution crystal structure of human TRAIL, a cytokine with selective antitumor activity., Cha SS, Kim MS, Choi YH, Sung BJ, Shin NK, Shin HC, Sung YC, Oh BH, Immunity. 1999 Aug;11(2):253-61. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10485660 10485660]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Cha, S S.]]
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[[Category: Cha S-S]]
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[[Category: Cytokine]]
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[[Category: Trail]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:13:35 2008''
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Current revision

CRYSTAL STRUCTURE OF HUMAN TRAIL

PDB ID 1d2q

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