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1d6h

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[[Image:1d6h.png|left|200px]]
 
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{{STRUCTURE_1d6h| PDB=1d6h | SCENE= }}
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==CHALONE SYNTHASE (N336A MUTANT COMPLEXED WITH COA)==
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<StructureSection load='1d6h' size='340' side='right'caption='[[1d6h]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1d6h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Medicago_sativa Medicago sativa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D6H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1D6H FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1d6h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d6h OCA], [https://pdbe.org/1d6h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1d6h RCSB], [https://www.ebi.ac.uk/pdbsum/1d6h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1d6h ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CHS2_MEDSA CHS2_MEDSA] The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.<ref>PMID:10653632</ref> <ref>PMID:11732902</ref> <ref>PMID:11959984</ref> <ref>PMID:15380179</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d6/1d6h_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1d6h ConSurf].
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<div style="clear:both"></div>
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===CHALONE SYNTHASE (N336A MUTANT COMPLEXED WITH COA)===
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==See Also==
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*[[Chalcone synthase|Chalcone synthase]]
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{{ABSTRACT_PUBMED_10653632}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1d6h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Medicago_sativa Medicago sativa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D6H OCA].
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</StructureSection>
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[[Category: Large Structures]]
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==Reference==
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<ref group="xtra">PMID:010653632</ref><references group="xtra"/>
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[[Category: Medicago sativa]]
[[Category: Medicago sativa]]
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[[Category: Naringenin-chalcone synthase]]
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[[Category: Bowman ME]]
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[[Category: Bowman, M E.]]
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[[Category: Dixon RA]]
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[[Category: Dixon, R A.]]
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[[Category: Ferrer JL]]
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[[Category: Ferrer, J L.]]
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[[Category: Jez JM]]
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[[Category: Jez, J M.]]
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[[Category: Noel JP]]
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[[Category: Noel, J P.]]
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[[Category: Flavonoid biosynthesis]]
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[[Category: Malonyl-coa decarboxylation]]
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[[Category: Polypetide synthase]]
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[[Category: Site-directed mutant]]
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[[Category: Transferase]]
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Current revision

CHALONE SYNTHASE (N336A MUTANT COMPLEXED WITH COA)

PDB ID 1d6h

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