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8gti
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Corticotropin-releasing hormone receptor 1(CRF1R) bound with BMK-C205 by XFEL== | |
| - | + | <StructureSection load='8gti' size='340' side='right'caption='[[8gti]], [[Resolution|resolution]] 2.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8gti]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterobacteria_phage_T6 Enterobacteria phage T6] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8GTI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8GTI FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0JS:8-(4-bromanyl-2,6-dimethoxy-phenyl)-~{N}-butyl-~{N}-(cyclopropylmethyl)-2,7-dimethyl-pyrazolo[1,5-a][1,3,5]triazin-4-amine'>0JS</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8gti FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8gti OCA], [https://pdbe.org/8gti PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8gti RCSB], [https://www.ebi.ac.uk/pdbsum/8gti PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8gti ProSAT]</span></td></tr> |
| - | [[Category: Cho | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CRFR1_HUMAN CRFR1_HUMAN] Receptor for corticotropin releasing factor (CRH). Shows high-affinity CRF binding. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.<ref>PMID:18801728</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Enterobacteria phage T6]] | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Cho HS]] | ||
| + | [[Category: Kim H]] | ||
Current revision
Corticotropin-releasing hormone receptor 1(CRF1R) bound with BMK-C205 by XFEL
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