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8kc7

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'''Unreleased structure'''
 
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The entry 8kc7 is ON HOLD until Paper Publication
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==Rpd3S histone deacetylase complex==
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<StructureSection load='8kc7' size='340' side='right'caption='[[8kc7]], [[Resolution|resolution]] 3.46&Aring;' scene=''>
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Authors: Dong, S., Li, H., Wang, M., Rasheed, N., Zou, B., Gao, X., Guan, J., Li, W., Zhang, J., Wang, C., Zhou, N., Shi, X., Li, M., Zhou, M., Huang, J., Li, H., Zhang, Y., Wong, K.H., Zhang, X., Chao, W.C.H., He, J.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8kc7]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8KC7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8KC7 FirstGlance]. <br>
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Description: Rpd3S histone deacetylase complex
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.46&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8kc7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8kc7 OCA], [https://pdbe.org/8kc7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8kc7 RCSB], [https://www.ebi.ac.uk/pdbsum/8kc7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8kc7 ProSAT]</span></td></tr>
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[[Category: Wang, M]]
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</table>
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[[Category: Li, H]]
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== Function ==
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[[Category: Dong, S]]
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[https://www.uniprot.org/uniprot/RPD3_YEAST RPD3_YEAST] Catalytic component of the RPD3 histone deacetylase (HDAC) complexes RPD3C(L) and RPD3C(S) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation plays an important role in transcriptional regulation, cell cycle progression, DNA damage response, osmotic stress response and developmental events. Is involved in rDNA and telomere silencing and in double strand breaks repair. Required for both full transcription repression and activation of many genes including cell type-specific genes (STE6, TY2 and HO), cell differentiation-specific genes (SPO13), genes that respond to external signals (PHO5) and TRK2. The RPD3 complexes regulate also chromosomal replication timing.<ref>PMID:10079324</ref> <ref>PMID:10359799</ref> <ref>PMID:10388812</ref> <ref>PMID:10931932</ref> <ref>PMID:11069890</ref> <ref>PMID:12089521</ref> <ref>PMID:12192044</ref> <ref>PMID:12808094</ref> <ref>PMID:14711989</ref> <ref>PMID:14737171</ref> <ref>PMID:15141165</ref> <ref>PMID:15143171</ref> <ref>PMID:15456858</ref> <ref>PMID:16286008</ref> <ref>PMID:1944291</ref> <ref>PMID:8962081</ref> <ref>PMID:8978024</ref> <ref>PMID:9512514</ref> <ref>PMID:9710596</ref>
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[[Category: Shi, X]]
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== References ==
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[[Category: Chao, W.C.H]]
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<references/>
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[[Category: Gao, X]]
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__TOC__
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[[Category: Li, W]]
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</StructureSection>
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[[Category: Zhang, X]]
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[[Category: Large Structures]]
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[[Category: Rasheed, N]]
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[[Category: Saccharomyces cerevisiae S288C]]
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[[Category: Guan, J]]
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[[Category: Chao WCH]]
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[[Category: Zhang, Y]]
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[[Category: Dong S]]
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[[Category: Wang, C]]
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[[Category: Gao X]]
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[[Category: He, J]]
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[[Category: Guan J]]
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[[Category: Li, M]]
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[[Category: He J]]
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[[Category: Huang, J]]
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[[Category: Huang J]]
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[[Category: Zhou, N]]
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[[Category: Li H]]
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[[Category: Zhou, M]]
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[[Category: Li M]]
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[[Category: Zhang, J]]
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[[Category: Li W]]
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[[Category: Zou, B]]
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[[Category: Rasheed N]]
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[[Category: Wong, K.H]]
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[[Category: Shi X]]
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[[Category: Wang C]]
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[[Category: Wang M]]
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[[Category: Wong KH]]
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[[Category: Zhang J]]
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[[Category: Zhang X]]
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[[Category: Zhang Y]]
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[[Category: Zhou M]]
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[[Category: Zhou N]]
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[[Category: Zou B]]

Current revision

Rpd3S histone deacetylase complex

PDB ID 8kc7

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