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8kd3

From Proteopedia

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'''Unreleased structure'''
 
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The entry 8kd3 is ON HOLD
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==Rpd3S in complex with nucleosome with H3K36MLA modification, H3K9Q mutation and 187bp DNA==
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<StructureSection load='8kd3' size='340' side='right'caption='[[8kd3]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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Authors: Dong, S., Li, H., Wang, M., Rasheed, N., Zou, B., Gao, X., Guan, J., Li, W., Zhang, J., Wang, C., Zhou, N., Shi, X., Li, M., Zhou, M., Huang, J., Li, H., Zhang, Y., Wong, C.K.H., Zhang, X., Chao, W.C.H., He, J.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8kd3]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae], [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8KD3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8KD3 FirstGlance]. <br>
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Description: Rpd3S in complex with nucleosome with H3K36MLA modification, H3K9Q mutation and 187bp DNA
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Wang, M]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8kd3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8kd3 OCA], [https://pdbe.org/8kd3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8kd3 RCSB], [https://www.ebi.ac.uk/pdbsum/8kd3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8kd3 ProSAT]</span></td></tr>
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[[Category: Li, H]]
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</table>
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[[Category: Dong, S]]
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== Function ==
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[[Category: Shi, X]]
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[https://www.uniprot.org/uniprot/RPD3_YEAST RPD3_YEAST] Catalytic component of the RPD3 histone deacetylase (HDAC) complexes RPD3C(L) and RPD3C(S) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation plays an important role in transcriptional regulation, cell cycle progression, DNA damage response, osmotic stress response and developmental events. Is involved in rDNA and telomere silencing and in double strand breaks repair. Required for both full transcription repression and activation of many genes including cell type-specific genes (STE6, TY2 and HO), cell differentiation-specific genes (SPO13), genes that respond to external signals (PHO5) and TRK2. The RPD3 complexes regulate also chromosomal replication timing.<ref>PMID:10079324</ref> <ref>PMID:10359799</ref> <ref>PMID:10388812</ref> <ref>PMID:10931932</ref> <ref>PMID:11069890</ref> <ref>PMID:12089521</ref> <ref>PMID:12192044</ref> <ref>PMID:12808094</ref> <ref>PMID:14711989</ref> <ref>PMID:14737171</ref> <ref>PMID:15141165</ref> <ref>PMID:15143171</ref> <ref>PMID:15456858</ref> <ref>PMID:16286008</ref> <ref>PMID:1944291</ref> <ref>PMID:8962081</ref> <ref>PMID:8978024</ref> <ref>PMID:9512514</ref> <ref>PMID:9710596</ref>
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[[Category: Chao, W.C.H]]
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== References ==
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[[Category: Gao, X]]
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<references/>
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[[Category: Li, W]]
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__TOC__
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[[Category: Zhang, X]]
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</StructureSection>
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[[Category: Rasheed, N]]
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[[Category: Large Structures]]
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[[Category: Zhang, Y]]
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[[Category: Saccharomyces cerevisiae]]
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[[Category: Guan, J]]
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[[Category: Synthetic construct]]
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[[Category: Wang, C]]
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[[Category: Xenopus laevis]]
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[[Category: Wong, C.K.H]]
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[[Category: Chao WCH]]
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[[Category: He, J]]
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[[Category: Dong S]]
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[[Category: Huang, J]]
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[[Category: Gao X]]
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[[Category: Li, M]]
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[[Category: Guan J]]
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[[Category: Zhou, N]]
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[[Category: He J]]
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[[Category: Zhou, M]]
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[[Category: Huang J]]
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[[Category: Zhang, J]]
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[[Category: Li H]]
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[[Category: Zou, B]]
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[[Category: Li M]]
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[[Category: Li W]]
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[[Category: Rasheed N]]
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[[Category: Shi X]]
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[[Category: Wang C]]
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[[Category: Wang M]]
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[[Category: Wong KH]]
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[[Category: Zhang J]]
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[[Category: Zhang X]]
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[[Category: Zhang Y]]
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[[Category: Zhou M]]
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[[Category: Zhou N]]
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[[Category: Zou B]]

Current revision

Rpd3S in complex with nucleosome with H3K36MLA modification, H3K9Q mutation and 187bp DNA

PDB ID 8kd3

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OCA

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