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3q2l

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[[Image:3q2l.jpg|left|200px]]
 
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==Mouse E-cadherin EC1-2 V81D mutant==
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The line below this paragraph, containing "STRUCTURE_3q2l", creates the "Structure Box" on the page.
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<StructureSection load='3q2l' size='340' side='right'caption='[[3q2l]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3q2l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q2L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q2L FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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{{STRUCTURE_3q2l| PDB=3q2l | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q2l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q2l OCA], [https://pdbe.org/3q2l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q2l RCSB], [https://www.ebi.ac.uk/pdbsum/3q2l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q2l ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CADH1_MOUSE CADH1_MOUSE] Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7 (By similarity). E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production (By similarity).
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===Mouse E-cadherin EC1-2 V81D mutant===
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==See Also==
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*[[Cadherin 3D structures|Cadherin 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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[[3q2l]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermomicrobium_roseum Thermomicrobium roseum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q2L OCA].
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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==Reference==
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[[Category: Harrison OJ]]
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<ref group="xtra">PMID:21300292</ref><references group="xtra"/>
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[[Category: Jin X]]
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[[Category: Thermomicrobium roseum]]
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[[Category: Shapiro L]]
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[[Category: Harrison, O J.]]
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[[Category: Jin, X.]]
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[[Category: Shapiro, L.]]
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Current revision

Mouse E-cadherin EC1-2 V81D mutant

PDB ID 3q2l

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