This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3q2l

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (11:30, 14 March 2024) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3q2l.png|left|200px]]
 
-
{{STRUCTURE_3q2l| PDB=3q2l | SCENE= }}
+
==Mouse E-cadherin EC1-2 V81D mutant==
-
 
+
<StructureSection load='3q2l' size='340' side='right'caption='[[3q2l]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
-
===Mouse E-cadherin EC1-2 V81D mutant===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[3q2l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q2L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q2L FirstGlance]. <br>
-
{{ABSTRACT_PUBMED_21300292}}
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-
==About this Structure==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q2l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q2l OCA], [https://pdbe.org/3q2l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q2l RCSB], [https://www.ebi.ac.uk/pdbsum/3q2l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q2l ProSAT]</span></td></tr>
-
[[3q2l]] is a 2 chain structure of [[Cadherin]] with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q2L OCA].
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/CADH1_MOUSE CADH1_MOUSE] Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7 (By similarity). E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production (By similarity).
==See Also==
==See Also==
-
*[[Cadherin|Cadherin]]
+
*[[Cadherin 3D structures|Cadherin 3D structures]]
-
 
+
__TOC__
-
==Reference==
+
</StructureSection>
-
<ref group="xtra">PMID:021300292</ref><references group="xtra"/>
+
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
-
[[Category: Harrison, O J.]]
+
[[Category: Harrison OJ]]
-
[[Category: Jin, X.]]
+
[[Category: Jin X]]
-
[[Category: Shapiro, L.]]
+
[[Category: Shapiro L]]
-
[[Category: Beta barrel fold]]
+
-
[[Category: Cell adhesion]]
+
-
[[Category: Cell-cell adhesion molecule]]
+
-
[[Category: Membrane]]
+

Current revision

Mouse E-cadherin EC1-2 V81D mutant

PDB ID 3q2l

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3q2l"
Personal tools