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3q33

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[[Image:3q33.png|left|200px]]
 
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{{STRUCTURE_3q33| PDB=3q33 | SCENE= }}
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==Structure of the Rtt109-AcCoA/Vps75 Complex and Implications for Chaperone-Mediated Histone Acetylation==
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<StructureSection load='3q33' size='340' side='right'caption='[[3q33]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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===Structure of the Rtt109-AcCoA/Vps75 Complex and Implications for Chaperone-Mediated Histone Acetylation===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3q33]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q33 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q33 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_21256037}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q33 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q33 OCA], [https://pdbe.org/3q33 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q33 RCSB], [https://www.ebi.ac.uk/pdbsum/3q33 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q33 ProSAT]</span></td></tr>
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[[3q33]] is a 3 chain structure of [[Histone acetyltransferase]] with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q33 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RT109_YEAST RT109_YEAST] Required for acetylation of 'Lys-56' of histone H3 (H3K56ac) which occurs in S phase and disappears during G(2)/M phase of the cell cycle and is involved in transcription DNA repair process. H3K56 acetylation weakens of the interaction between the histone core and the surrounding DNA in the nucleosomal particle and drives chromatin disassembly. Involved in regulation of Ty1 transposition.<ref>PMID:11779788</ref> <ref>PMID:17046836</ref> <ref>PMID:17369253</ref> <ref>PMID:17690098</ref> <ref>PMID:17320445</ref> <ref>PMID:17272722</ref> <ref>PMID:17272723</ref> <ref>PMID:18577595</ref> <ref>PMID:18723682</ref>
==See Also==
==See Also==
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*[[Histone acetyltransferase|Histone acetyltransferase]]
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*[[Histone acetyltransferase 3D structures|Histone acetyltransferase 3D structures]]
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*[[Vacuolar protein sorting-associated protein 3D structures|Vacuolar protein sorting-associated protein 3D structures]]
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==Reference==
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== References ==
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<ref group="xtra">PMID:021256037</ref><ref group="xtra">PMID:018568037</ref><ref group="xtra">PMID:018723682</ref><references group="xtra"/>
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<references/>
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[[Category: Histone acetyltransferase]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Marmorstein, R.]]
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[[Category: Synthetic construct]]
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[[Category: Meeth, K.]]
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[[Category: Marmorstein R]]
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[[Category: Tang, Y.]]
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[[Category: Meeth K]]
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[[Category: Yuan, H.]]
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[[Category: Tang Y]]
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[[Category: Autoacetylation on rtt109 lys290]]
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[[Category: Yuan H]]
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[[Category: Chaperone-gene regulation complex]]
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[[Category: Histone acetyltransferase]]
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[[Category: Nuclear]]
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[[Category: Rtt109:vps75=2:2 stoichiometry complex]]
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[[Category: Transferase]]
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[[Category: Transferase-chaperone complex]]
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[[Category: Transferase-chaperone-transcription regulator complex]]
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Current revision

Structure of the Rtt109-AcCoA/Vps75 Complex and Implications for Chaperone-Mediated Histone Acetylation

PDB ID 3q33

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