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3q92
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| - | {{STRUCTURE_3q92| PDB=3q92 | SCENE= }} | ||
| - | ===X-ray Structure of ketohexokinase in complex with a pyrimidopyrimidine analog 1=== | ||
| - | == | + | ==X-ray Structure of ketohexokinase in complex with a pyrimidopyrimidine analog 1== |
| - | [[http://www.uniprot.org/uniprot/KHK_HUMAN KHK_HUMAN | + | <StructureSection load='3q92' size='340' side='right'caption='[[3q92]], [[Resolution|resolution]] 2.80Å' scene=''> |
| - | + | == Structural highlights == | |
| - | == | + | <table><tr><td colspan='2'>[[3q92]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q92 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q92 FirstGlance]. <br> |
| - | [ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=XNB:N~8~-(CYCLOPROPYLMETHYL)-N~4~-[2-(METHYLSULFANYL)PHENYL]-2-(PIPERAZIN-1-YL)PYRIMIDO[5,4-D]PYRIMIDINE-4,8-DIAMINE'>XNB</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q92 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q92 OCA], [https://pdbe.org/3q92 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q92 RCSB], [https://www.ebi.ac.uk/pdbsum/3q92 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q92 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/KHK_HUMAN KHK_HUMAN] Defects in KHK are the cause of fructosuria (FRUCT) [MIM:[https://omim.org/entry/229800 229800]. Benign defect of intermediary metabolism.<ref>PMID:19237742</ref> <ref>PMID:7833921</ref> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/KHK_HUMAN KHK_HUMAN] | ||
==See Also== | ==See Also== | ||
*[[Ketohexokinase|Ketohexokinase]] | *[[Ketohexokinase|Ketohexokinase]] | ||
| - | + | == References == | |
| - | == | + | <references/> |
| - | <references | + | __TOC__ |
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Abad | + | [[Category: Abad MC]] |
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
X-ray Structure of ketohexokinase in complex with a pyrimidopyrimidine analog 1
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