3qen
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3qen is ON HOLD Authors: Lavie, A., Hazra, S. Description: S74E dCK in complex with 5-bromodeoxycytidine and UDP) |
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| - | '''Unreleased structure''' | ||
| - | + | ==S74E dCK in complex with 5-bromodeoxycytidine and UDP== | |
| + | <StructureSection load='3qen' size='340' side='right'caption='[[3qen]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3qen]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QEN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QEN FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.997Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5BT:5-BROMO-2-DEOXYCYTIDINE'>5BT</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qen FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qen OCA], [https://pdbe.org/3qen PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qen RCSB], [https://www.ebi.ac.uk/pdbsum/3qen PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qen ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DCK_HUMAN DCK_HUMAN] Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.<ref>PMID:18377927</ref> <ref>PMID:20614893</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Deoxycytidine kinase 3D structures|Deoxycytidine kinase 3D structures]] | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Hazra S]] | ||
| + | [[Category: Lavie A]] | ||
Current revision
S74E dCK in complex with 5-bromodeoxycytidine and UDP
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