3qen

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{{STRUCTURE_3qen| PDB=3qen | SCENE= }}
 
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===S74E dCK in complex with 5-bromodeoxycytidine and UDP===
 
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{{ABSTRACT_PUBMED_21351740}}
 
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==Function==
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==S74E dCK in complex with 5-bromodeoxycytidine and UDP==
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[[http://www.uniprot.org/uniprot/DCK_HUMAN DCK_HUMAN]] Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.<ref>PMID:18377927</ref> <ref>PMID:20614893</ref>
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<StructureSection load='3qen' size='340' side='right'caption='[[3qen]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[3qen]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QEN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QEN FirstGlance]. <br>
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[[3qen]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QEN OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.997&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5BT:5-BROMO-2-DEOXYCYTIDINE'>5BT</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qen FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qen OCA], [https://pdbe.org/3qen PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qen RCSB], [https://www.ebi.ac.uk/pdbsum/3qen PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qen ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DCK_HUMAN DCK_HUMAN] Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.<ref>PMID:18377927</ref> <ref>PMID:20614893</ref>
==See Also==
==See Also==
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*[[Deoxycytidine kinase|Deoxycytidine kinase]]
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*[[Deoxycytidine kinase 3D structures|Deoxycytidine kinase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:021351740</ref><references group="xtra"/><references/>
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__TOC__
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[[Category: Deoxycytidine kinase]]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Hazra, S.]]
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[[Category: Large Structures]]
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[[Category: Lavie, A.]]
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[[Category: Hazra S]]
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[[Category: Alpha/beta]]
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[[Category: Lavie A]]
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[[Category: Phosphoryl transfer]]
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[[Category: Phosphorylation]]
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[[Category: Transferase]]
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Current revision

S74E dCK in complex with 5-bromodeoxycytidine and UDP

PDB ID 3qen

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