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3qi5

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[[Image:3qi5.png|left|200px]]
 
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{{STRUCTURE_3qi5| PDB=3qi5 | SCENE= }}
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==Crystal structure of human alkyladenine DNA glycosylase in complex with 3,N4-ethenocystosine containing duplex DNA==
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<StructureSection load='3qi5' size='340' side='right'caption='[[3qi5]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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===Crystal structure of human alkyladenine DNA glycosylase in complex with 3,N4-ethenocystosine containing duplex DNA===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3qi5]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QI5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QI5 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_21349833}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDC:N3,N4-ETHENO-2-DEOXYCYTIDINE-5-MONOPHOSPHATE'>EDC</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qi5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qi5 OCA], [https://pdbe.org/3qi5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qi5 RCSB], [https://www.ebi.ac.uk/pdbsum/3qi5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qi5 ProSAT]</span></td></tr>
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[[3qi5]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QI5 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/3MG_HUMAN 3MG_HUMAN] Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions.
==See Also==
==See Also==
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*[[DNA glycosylate|DNA glycosylate]]
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*[[DNA glycosylase 3D structures|DNA glycosylase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:021349833</ref><references group="xtra"/>
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[[Category: DNA-3-methyladenine glycosylase II]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Davis, C A.]]
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[[Category: Large Structures]]
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[[Category: Drennan, C L.]]
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[[Category: Davis CA]]
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[[Category: Lingaraju, G M.]]
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[[Category: Drennan CL]]
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[[Category: Samson, L D.]]
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[[Category: Lingaraju GM]]
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[[Category: Setser, J W.]]
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[[Category: Samson LD]]
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[[Category: Aag]]
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[[Category: Setser JW]]
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[[Category: Alkyladenine dna glycosylase fold]]
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[[Category: Dna binding]]
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[[Category: Dna repair]]
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[[Category: Excision]]
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[[Category: Hydrolase-dna complex]]
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[[Category: Nucleus]]
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Current revision

Crystal structure of human alkyladenine DNA glycosylase in complex with 3,N4-ethenocystosine containing duplex DNA

PDB ID 3qi5

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