3qk5

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[[Image:3qk5.jpg|left|200px]]
 
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==Crystal structure of fatty acid amide hydrolase with small molecule inhibitor==
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The line below this paragraph, containing "STRUCTURE_3qk5", creates the "Structure Box" on the page.
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<StructureSection load='3qk5' size='340' side='right'caption='[[3qk5]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3qk5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QK5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QK5 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=QK5:(3-{(3R)-1-[4-(1-BENZOTHIOPHEN-2-YL)PYRIMIDIN-2-YL]PIPERIDIN-3-YL}-2-METHYL-1H-PYRROLO[2,3-B]PYRIDIN-1-YL)ACETONITRILE'>QK5</scene></td></tr>
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{{STRUCTURE_3qk5| PDB=3qk5 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qk5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qk5 OCA], [https://pdbe.org/3qk5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qk5 RCSB], [https://www.ebi.ac.uk/pdbsum/3qk5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qk5 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FAAH1_RAT FAAH1_RAT] Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (By similarity).
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===Crystal structure of fatty acid amide hydrolase with small molecule inhibitor===
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==See Also==
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*[[Fatty acid amide hydrolase|Fatty acid amide hydrolase]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 21392988 is the PubMed ID number.
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{{ABSTRACT_PUBMED_21392988}}
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==About this Structure==
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[[3qk5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QK5 OCA].
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==Reference==
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<ref group="xtra">PMID:21392988</ref><references group="xtra"/>
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[[Category: Fatty acid amide hydrolase]]
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[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Min, X.]]
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[[Category: Min X]]
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[[Category: Walker, N P.C.]]
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[[Category: Walker NPC]]
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[[Category: Wang, Z.]]
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[[Category: Wang Z]]

Current revision

Crystal structure of fatty acid amide hydrolase with small molecule inhibitor

PDB ID 3qk5

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