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3qmg

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Structural Basis of Selective Binding of Non-Methylated CpG islands by the CXXC Domain of CFP1

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 ==Structural Basis of Selective Binding of Non-Methylated CpG islands by the CXXC Domain of CFP1==
-<StructureSection load='3qmg' size='340' side='right' caption='[[3qmg]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
+<StructureSection load='3qmg' size='340' side='right'caption='[[3qmg]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[3qmg]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QMG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QMG FirstGlance]. <br>
+<table><tr><td colspan='2'>[[3qmg]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QMG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QMG FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3qmb|3qmb]], [[3qmc|3qmc]], [[3qmd|3qmd]], [[3qmh|3qmh]], [[3qmi|3qmi]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CFP1, CGBP, CXXC1, PCCX1, PHF18 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qmg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qmg OCA], [https://pdbe.org/3qmg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qmg RCSB], [https://www.ebi.ac.uk/pdbsum/3qmg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qmg ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qmg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qmg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qmg RCSB], [http://www.ebi.ac.uk/pdbsum/3qmg PDBsum]</span></td></tr>
 </table>
-<div style="background-color:#fffaf0;">
+== Function ==
-== Publication Abstract from PubMed ==
+[https://www.uniprot.org/uniprot/CXXC1_HUMAN CXXC1_HUMAN] Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG.<ref>PMID:21407193</ref>
-CFP1 is a CXXC domain-containing protein and an essential component of the SETD1 histone H3K4 methyltransferase complex. CXXC domain proteins direct different chromatin-modifying activities to various chromatin regions. Here, we report crystal structures of the CFP1 CXXC domain in complex with six different CpG DNA sequences. The crescent-shaped CFP1 CXXC domain is wedged into the major groove of the CpG DNA, distorting the B-form DNA, and interacts extensively with the major groove of the DNA. The structures elucidate the molecular mechanism of the non-methylated CpG-binding specificity of the CFP1 CXXC domain. The CpG motif is confined by a tripeptide located in a rigid loop, which only allows the accommodation of the non-methylated CpG dinucleotide. Furthermore, we demonstrate that CFP1 has a preference for a guanosine nucleotide following the CpG motif.
-The structural basis for selective binding of non-methylated CpG islands by the CFP1 CXXC domain.,Xu C, Bian C, Lam R, Dong A, Min J Nat Commun. 2011 Mar;2:227. PMID:21407193<ref>PMID:21407193</ref>
-From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-</div>
 == References ==
 <references/>
@@ Line 21: / Line 15: @@
 </StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Arrowsmith, C H]]
+[[Category: Large Structures]]
-[[Category: Bian, C]]
+[[Category: Arrowsmith CH]]
-[[Category: Bountra, C]]
+[[Category: Bian C]]
-[[Category: Edwards, A M]]
+[[Category: Bountra C]]
-[[Category: MacKenzie, F]]
+[[Category: Edwards AM]]
-[[Category: Min, J]]
+[[Category: MacKenzie F]]
-[[Category: Structural genomic]]
+[[Category: Min J]]
-[[Category: Weigelt, J]]
+[[Category: Weigelt J]]
-[[Category: Xu, C]]
+[[Category: Xu C]]
-[[Category: Dna binding protein-dna complex]]
-[[Category: Protein-dna complex]]
-[[Category: Sgc]]

3qmg

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Structural Basis of Selective Binding of Non-Methylated CpG islands by the CXXC Domain of CFP1

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