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3qnf

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[[Image:3qnf.png|left|200px]]
 
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{{STRUCTURE_3qnf| PDB=3qnf | SCENE= }}
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==Crystal structure of the open state of human endoplasmic reticulum aminopeptidase 1 ERAP1==
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<StructureSection load='3qnf' size='340' side='right'caption='[[3qnf]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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===Crystal structure of the open state of human endoplasmic reticulum aminopeptidase 1 ERAP1===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3qnf]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QNF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QNF FirstGlance]. <br>
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{{ABSTRACT_PUBMED_21508329}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qnf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qnf OCA], [https://pdbe.org/3qnf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qnf RCSB], [https://www.ebi.ac.uk/pdbsum/3qnf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qnf ProSAT]</span></td></tr>
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[[3qnf]] is a 3 chain structure of [[Aminopeptidase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QNF OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ERAP1_HUMAN ERAP1_HUMAN] Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney.<ref>PMID:15908954</ref> <ref>PMID:16286653</ref> <ref>PMID:21478864</ref>
==See Also==
==See Also==
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*[[Aminopeptidase|Aminopeptidase]]
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*[[Aminopeptidase 3D structures|Aminopeptidase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:021508329</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Allerston, C.]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Allerston C]]
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[[Category: Berridge, G.]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra, C.]]
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[[Category: Berridge G]]
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[[Category: Chaikuad, A.]]
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[[Category: Bountra C]]
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[[Category: DELFT, F von.]]
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[[Category: Chaikuad A]]
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[[Category: Edwards, A.]]
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[[Category: Edwards A]]
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[[Category: Harvey, D.]]
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[[Category: Harvey D]]
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[[Category: Kavanagh, K.]]
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[[Category: Kavanagh K]]
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[[Category: Kochan, G.]]
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[[Category: Kochan G]]
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[[Category: Krojer, T.]]
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[[Category: Krojer T]]
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[[Category: Muniz, J R.C.]]
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[[Category: Muniz JRC]]
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[[Category: Oppermann, U.]]
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[[Category: Oppermann U]]
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[[Category: Raynor, J.]]
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[[Category: Raynor J]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Ugochukwu E]]
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[[Category: Ugochukwu, E.]]
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[[Category: Vollmar M]]
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[[Category: Vollmar, M.]]
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[[Category: Wordsworth BP]]
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[[Category: Wordsworth, B P.]]
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[[Category: Von Delft F]]
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[[Category: Adaptive immunity]]
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[[Category: Glycoprotein]]
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[[Category: Hydrolase]]
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[[Category: Metal-binding]]
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[[Category: Metalloprotease]]
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[[Category: Protease]]
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[[Category: Sgc]]
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[[Category: Structural genomics consortium]]
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Current revision

Crystal structure of the open state of human endoplasmic reticulum aminopeptidase 1 ERAP1

PDB ID 3qnf

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