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3qo2
From Proteopedia
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| - | [[Image:3qo2.jpg|left|200px]] | ||
| - | + | ==Structural insights for MPP8 chromodomain interaction with histone H3 lysine 9== | |
| - | + | <StructureSection load='3qo2' size='340' side='right'caption='[[3qo2]], [[Resolution|resolution]] 2.49Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3qo2]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QO2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QO2 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.49Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qo2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qo2 OCA], [https://pdbe.org/3qo2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qo2 RCSB], [https://www.ebi.ac.uk/pdbsum/3qo2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qo2 ProSAT]</span></td></tr> | |
| - | + | </table> | |
| - | + | == Function == | |
| - | + | [https://www.uniprot.org/uniprot/MPP8_HUMAN MPP8_HUMAN] Involved in transcriptional regulation. Specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene. Mediates down-regulation of CDH1 expression.<ref>PMID:20871592</ref> | |
| - | + | == References == | |
| - | < | + | <references/> |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
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| - | == | + | |
| - | [[3qo2]] is a 8 chain structure with sequence from [ | + | |
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| - | == | + | |
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Bedford | + | [[Category: Large Structures]] |
| - | [[Category: Chang | + | [[Category: Synthetic construct]] |
| - | [[Category: Cheng | + | [[Category: Bedford MT]] |
| - | [[Category: Horton | + | [[Category: Chang Y]] |
| - | [[Category: Zhang | + | [[Category: Cheng X]] |
| + | [[Category: Horton JR]] | ||
| + | [[Category: Zhang X]] | ||
Current revision
Structural insights for MPP8 chromodomain interaction with histone H3 lysine 9
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