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3r1l

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[[Image:3r1l.jpg|left|200px]]
 
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==Crystal structure of the Class I ligase ribozyme-substrate preligation complex, C47U mutant, Mg2+ bound==
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The line below this paragraph, containing "STRUCTURE_3r1l", creates the "Structure Box" on the page.
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<StructureSection load='3r1l' size='340' side='right'caption='[[3r1l]], [[Resolution|resolution]] 3.12&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3r1l]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R1L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3R1L FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.125&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A23:ADENOSINE-5-PHOSPHATE-2,3-CYCLIC+PHOSPHATE'>A23</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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{{STRUCTURE_3r1l| PDB=3r1l | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3r1l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3r1l OCA], [https://pdbe.org/3r1l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3r1l RCSB], [https://www.ebi.ac.uk/pdbsum/3r1l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3r1l ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SNRPA_HUMAN SNRPA_HUMAN] Binds stem loop II of U1 snRNA. It is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. Binds preferentially to the 5'-UGCAC-3' motif in vitro.<ref>PMID:9848648</ref>
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===Crystal structure of the Class I ligase ribozyme-substrate preligation complex, C47U mutant, Mg2+ bound===
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==See Also==
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*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
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*[[Ribozyme 3D structures|Ribozyme 3D structures]]
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==About this Structure==
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== References ==
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[[3r1l]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R1L OCA].
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bartel, D P.]]
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[[Category: Large Structures]]
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[[Category: Shechner, D M.]]
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[[Category: Bartel DP]]
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[[Category: Catalytic rna]]
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[[Category: Shechner DM]]
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[[Category: Ligase ribozyme]]
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[[Category: Ribozyme]]
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[[Category: Rna binding protein-rna complex]]
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Current revision

Crystal structure of the Class I ligase ribozyme-substrate preligation complex, C47U mutant, Mg2+ bound

PDB ID 3r1l

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