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3r4l

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[[Image:3r4l.jpg|left|200px]]
 
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==Human very long half life Plasminogen Activator Inhibitor type-1==
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The line below this paragraph, containing "STRUCTURE_3r4l", creates the "Structure Box" on the page.
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<StructureSection load='3r4l' size='340' side='right'caption='[[3r4l]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3r4l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R4L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3R4L FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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{{STRUCTURE_3r4l| PDB=3r4l | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3r4l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3r4l OCA], [https://pdbe.org/3r4l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3r4l RCSB], [https://www.ebi.ac.uk/pdbsum/3r4l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3r4l ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/PAI1_HUMAN PAI1_HUMAN] Defects in SERPINE1 are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1D) [MIM:[https://omim.org/entry/613329 613329]. It is a hematologic disorder characterized by increased bleeding after trauma, injury, or surgery. Affected females have menorrhagia. The bleeding defect is due to increased fibrinolysis of fibrin blood clots due to deficiency of plasminogen activator inhibitor-1, which inhibits tissue and urinary activators of plasminogen.<ref>PMID:9207454</ref> Note=High concentrations of SERPINE1 seem to contribute to the development of venous but not arterial occlusions.
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== Function ==
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[https://www.uniprot.org/uniprot/PAI1_HUMAN PAI1_HUMAN] Serine protease inhibitor. This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis.<ref>PMID:15853774</ref>
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===Human very long half life Plasminogen Activator Inhibitor type-1===
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==See Also==
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*[[Plasminogen activator inhibitor|Plasminogen activator inhibitor]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_21947232}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 21947232 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_21947232}}
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==About this Structure==
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[[3r4l]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R4L OCA].
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==Reference==
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<ref group="xtra">PMID:021947232</ref><ref group="xtra">PMID:012533669</ref><ref group="xtra">PMID:019082507</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Han, Q.]]
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[[Category: Large Structures]]
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[[Category: Jankun, J.]]
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[[Category: Han Q]]
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[[Category: Skrzypczak-Jankun, E.]]
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[[Category: Jankun J]]
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[[Category: Yang, J.]]
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[[Category: Skrzypczak-Jankun E]]
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[[Category: Zheng, H.]]
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[[Category: Yang J]]
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[[Category: Blood clotting]]
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[[Category: Zheng H]]
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[[Category: Carbohydrate]]
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[[Category: Pai-1]]
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[[Category: Plasminogen activator inhibitor type 1]]
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[[Category: Serine protease inhibitor]]
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[[Category: Very long half life]]
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Current revision

Human very long half life Plasminogen Activator Inhibitor type-1

PDB ID 3r4l

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