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3r9x

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{{STRUCTURE_3r9x| PDB=3r9x | SCENE= }}
 
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===Crystal structure of Era in complex with MgGDPNP, nucleotides 1506-1542 of 16S ribosomal RNA, and KsgA===
 
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{{ABSTRACT_PUBMED_21646538}}
 
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==Function==
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==Crystal structure of Era in complex with MgGDPNP, nucleotides 1506-1542 of 16S ribosomal RNA, and KsgA==
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[[http://www.uniprot.org/uniprot/ERA_AQUAE ERA_AQUAE]] An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity). The GTPase is stimulated about 6-fold in the presence of a 12 nucleotide 16S rRNA C-terminal fragment. Mutations in the rRNA sequence obviate stimulation. RNA-binding depends on GTP-binding by the GTPase domain. May function as a checkpoint for assembly of the 30S ribosomal subunit. [[http://www.uniprot.org/uniprot/RSMA_AQUAE RSMA_AQUAE]] Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity).
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<StructureSection load='3r9x' size='340' side='right'caption='[[3r9x]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3r9x]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R9X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3R9X FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3r9x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3r9x OCA], [https://pdbe.org/3r9x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3r9x RCSB], [https://www.ebi.ac.uk/pdbsum/3r9x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3r9x ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RSMA_AQUAE RSMA_AQUAE] Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity).
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==About this Structure==
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==See Also==
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[[3r9x]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R9X OCA].
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*[[Adenosine dimethyltransferase 3D structures|Adenosine dimethyltransferase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:021646538</ref><ref group="xtra">PMID:019706445</ref><references group="xtra"/><references/>
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[[Category: Aquifex aeolicus]]
[[Category: Aquifex aeolicus]]
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[[Category: Ji, X.]]
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[[Category: Large Structures]]
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[[Category: Tu, C.]]
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[[Category: Ji X]]
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[[Category: 16s ribosomal rna]]
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[[Category: Tu C]]
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[[Category: Biogenesis]]
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[[Category: Gtp]]
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[[Category: Gtp hydrolysis]]
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[[Category: Gtpase]]
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[[Category: Hydrolase-transferase-rna complex]]
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[[Category: Kh domain]]
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[[Category: Ribosome]]
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Current revision

Crystal structure of Era in complex with MgGDPNP, nucleotides 1506-1542 of 16S ribosomal RNA, and KsgA

PDB ID 3r9x

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