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3rab

From Proteopedia

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{{Seed}}
 
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[[Image:3rab.png|left|200px]]
 
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==GPPNHP-BOUND RAB3A AT 2.0 A RESOLUTION==
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The line below this paragraph, containing "STRUCTURE_3rab", creates the "Structure Box" on the page.
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<StructureSection load='3rab' size='340' side='right'caption='[[3rab]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3rab]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RAB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RAB FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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{{STRUCTURE_3rab| PDB=3rab | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rab FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rab OCA], [https://pdbe.org/3rab PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rab RCSB], [https://www.ebi.ac.uk/pdbsum/3rab PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rab ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RAB3A_RAT RAB3A_RAT] Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ra/3rab_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3rab ConSurf].
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<div style="clear:both"></div>
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===GPPNHP-BOUND RAB3A AT 2.0 A RESOLUTION===
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==See Also==
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*[[Ras-related protein Rab 3D structures|Ras-related protein Rab 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_10196122}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 10196122 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10196122}}
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==About this Structure==
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3RAB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RAB OCA].
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==Reference==
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Structural basis of activation and GTP hydrolysis in Rab proteins., Dumas JJ, Zhu Z, Connolly JL, Lambright DG, Structure. 1999 Apr 15;7(4):413-23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10196122 10196122]
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[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Single protein]]
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[[Category: Connolly JL]]
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[[Category: Connolly, J L.]]
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[[Category: Dumas JJ]]
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[[Category: Dumas, J J.]]
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[[Category: Lambright DG]]
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[[Category: Lambright, D G.]]
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[[Category: Zhu Z]]
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[[Category: Zhu, Z.]]
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[[Category: G protein]]
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[[Category: Gtp hydrolysis]]
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[[Category: Hydrolase]]
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[[Category: Neurotransmitter release]]
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[[Category: Rab protein]]
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[[Category: Vesicular trafficking]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 13:04:39 2008''
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Current revision

GPPNHP-BOUND RAB3A AT 2.0 A RESOLUTION

PDB ID 3rab

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