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3rau

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[[Image:3rau.png|left|200px]]
 
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{{STRUCTURE_3rau| PDB=3rau | SCENE= }}
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==Crystal structure of the HD-PTP Bro1 domain==
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<StructureSection load='3rau' size='340' side='right'caption='[[3rau]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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===Crystal structure of the HD-PTP Bro1 domain===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3rau]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RAU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RAU FirstGlance]. <br>
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{{ABSTRACT_PUBMED_21889351}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rau FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rau OCA], [https://pdbe.org/3rau PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rau RCSB], [https://www.ebi.ac.uk/pdbsum/3rau PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rau ProSAT]</span></td></tr>
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[[3rau]] is a 2 chain structure of [[Proten tyrosine phosphatase]] and [[Tyrosine phosphatase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RAU OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PTN23_HUMAN PTN23_HUMAN] Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes. May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis.<ref>PMID:18434552</ref> <ref>PMID:20393563</ref> <ref>PMID:21757351</ref>
==See Also==
==See Also==
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*[[Proten tyrosine phosphatase|Proten tyrosine phosphatase]]
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*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
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*[[Tyrosine phosphatase|Tyrosine phosphatase]]
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:021889351</ref><references group="xtra"/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein-tyrosine-phosphatase]]
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[[Category: Large Structures]]
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[[Category: Jiang, J S.]]
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[[Category: Jiang JS]]
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[[Category: Mu, R L.]]
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[[Category: Mu RL]]
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[[Category: Smith, P.]]
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[[Category: Smith P]]
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[[Category: Snyder, G.]]
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[[Category: Snyder G]]
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[[Category: Xiao, T.]]
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[[Category: Xiao T]]
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[[Category: Bro1 domain]]
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[[Category: Hydrolase]]
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Current revision

Crystal structure of the HD-PTP Bro1 domain

PDB ID 3rau

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