3rg0
From Proteopedia
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| - | [[Image:3rg0.jpg|left|200px]] | ||
| - | < | + | ==Structural and functional relationships between the lectin and arm domains of calreticulin== |
| - | + | <StructureSection load='3rg0' size='340' side='right'caption='[[3rg0]], [[Resolution|resolution]] 2.57Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3rg0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RG0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RG0 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.57Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rg0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rg0 OCA], [https://pdbe.org/3rg0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rg0 RCSB], [https://www.ebi.ac.uk/pdbsum/3rg0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rg0 ProSAT]</span></td></tr> | |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CALR_MOUSE CALR_MOUSE] Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity).<ref>PMID:20880849</ref> <ref>PMID:21652723</ref> | ||
| - | == | + | ==See Also== |
| - | + | *[[Calreticulin 3D structures|Calreticulin 3D structures]] | |
| - | + | == References == | |
| - | == | + | <references/> |
| - | [[ | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | [[Category: Brockmeier | + | [[Category: Brockmeier U]] |
| - | [[Category: Gehring | + | [[Category: Gehring K]] |
| - | [[Category: Kozlov | + | [[Category: Kozlov G]] |
| - | [[Category: Pocanschi | + | [[Category: Pocanschi CL]] |
| - | [[Category: Williams | + | [[Category: Williams DB]] |
Current revision
Structural and functional relationships between the lectin and arm domains of calreticulin
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