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3rh4
From Proteopedia
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| - | [[Image:3rh4.png|left|200px]] | ||
| - | + | ==DNA Polymerase Beta with a dideoxy-terminated primer with an incoming ribonucleotide (rCTP)== | |
| - | + | <StructureSection load='3rh4' size='340' side='right'caption='[[3rh4]], [[Resolution|resolution]] 1.92Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3rh4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RH4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RH4 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.918Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CTP:CYTIDINE-5-TRIPHOSPHATE'>CTP</scene>, <scene name='pdbligand=DDG:2,3-DIDEOXY-GUANOSINE-5-MONOPHOSPHATE'>DDG</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rh4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rh4 OCA], [https://pdbe.org/3rh4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rh4 RCSB], [https://www.ebi.ac.uk/pdbsum/3rh4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rh4 ProSAT]</span></td></tr> |
| - | [[3rh4]] is a 4 chain structure | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DPOLB_HUMAN DPOLB_HUMAN] Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.<ref>PMID:9207062</ref> <ref>PMID:9572863</ref> <ref>PMID:11805079</ref> <ref>PMID:21362556</ref> | ||
==See Also== | ==See Also== | ||
| - | *[[DNA polymerase|DNA polymerase]] | + | *[[DNA polymerase 3D structures|DNA polymerase 3D structures]] |
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Batra | + | [[Category: Large Structures]] |
| - | [[Category: Beard | + | [[Category: Batra VK]] |
| - | [[Category: Cavanaugh | + | [[Category: Beard WA]] |
| - | [[Category: Pedersen | + | [[Category: Cavanaugh NA]] |
| - | [[Category: Perera | + | [[Category: Pedersen LG]] |
| - | [[Category: Wilson | + | [[Category: Perera L]] |
| - | + | [[Category: Wilson SH]] | |
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Current revision
DNA Polymerase Beta with a dideoxy-terminated primer with an incoming ribonucleotide (rCTP)
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