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3ri4

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Current revision (12:24, 14 March 2024) (edit) (undo)
 
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<StructureSection load='3ri4' size='340' side='right'caption='[[3ri4]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
<StructureSection load='3ri4' size='340' side='right'caption='[[3ri4]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3ri4]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RI4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RI4 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3ri4]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RI4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RI4 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3mfk|3mfk]], [[1gvj|1gvj]]</div></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ETS1, EWSR2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ri4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ri4 OCA], [https://pdbe.org/3ri4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ri4 RCSB], [https://www.ebi.ac.uk/pdbsum/3ri4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ri4 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ri4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ri4 OCA], [https://pdbe.org/3ri4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ri4 RCSB], [https://www.ebi.ac.uk/pdbsum/3ri4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ri4 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/ETS1_HUMAN ETS1_HUMAN]] Transcription factor.<ref>PMID:10698492</ref>
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[https://www.uniprot.org/uniprot/ETS1_HUMAN ETS1_HUMAN] Transcription factor.<ref>PMID:10698492</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Ets1 is a member of the Ets family of transcription factors. Ets1 is expressed in autoinhibited form and its DNA binding depends on partner proteins bound to adjacent sequences or the relative positioning of a second Ets-binding site (EBS). The autoinhibition of Ets1 is mediated by structural coupling of regions flanking the DNA-binding domain. The NMR structure of Ets1 revealed that the inhibitory regions comprised of helices HI1 and HI2 and H4 are packed together on the Ets domain to form an inhibitory module. The crystal structure of Ets1 unexpectedly revealed a homodimer in which homodimerisation occurs via swapping of HI1 helices. Modeling of DNA binding indicates that the Ets1 dimer can bind to two antiparallel pieces of DNA. To verify this, we crystallized and solved the structure of the complex comprised of Ets1 dimer and two pieces of DNA. DNA binding by Ets1 dimer resulted in formation of additional intermolecular protein*DNA interactions, implying that the complex formation is cooperative.
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Structural basis of ets1 cooperative binding to widely separated sites on promoter DNA.,Babayeva ND, Baranovskaya OI, Tahirov TH PLoS One. 2012;7(3):e33698. Epub 2012 Mar 14. PMID:22432043<ref>PMID:22432043</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3ri4" style="background-color:#fffaf0;"></div>
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==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Babayeva, N D]]
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[[Category: Babayeva ND]]
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[[Category: Mino, K]]
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[[Category: Mino K]]
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[[Category: Tahirov, T H]]
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[[Category: Tahirov TH]]
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[[Category: Autoinhibition]]
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[[Category: Dna]]
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[[Category: Dna binding]]
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[[Category: Ets domain]]
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[[Category: Runx1]]
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[[Category: Runx2]]
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[[Category: T-cell receptor alpha]]
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[[Category: Transcription]]
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[[Category: Transcription factor]]
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[[Category: Transcription-dna complex]]
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Current revision

Ets1 cooperative binding to widely separated sites on promoter DNA

PDB ID 3ri4

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