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3rlh

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[[Image:3rlh.png|left|200px]]
 
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{{STRUCTURE_3rlh| PDB=3rlh | SCENE= }}
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==Crystal structure of a class II phospholipase D from Loxosceles intermedia venom==
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<StructureSection load='3rlh' size='340' side='right'caption='[[3rlh]], [[Resolution|resolution]] 1.72&Aring;' scene=''>
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===Crystal structure of a class II phospholipase D from Loxosceles intermedia venom===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3rlh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Loxosceles_intermedia Loxosceles intermedia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RLH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RLH FirstGlance]. <br>
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{{ABSTRACT_PUBMED_21616057}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.72&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rlh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rlh OCA], [https://pdbe.org/3rlh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rlh RCSB], [https://www.ebi.ac.uk/pdbsum/3rlh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rlh ProSAT]</span></td></tr>
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[[3rlh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Loxosceles_intermedia Loxosceles intermedia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RLH OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/A1HA_LOXIN A1HA_LOXIN] Catalyzes the hydrolysis of sphingomyelin, lysophosphatidylcholine, and lyso-platelet activating factor but not that of phosphatidylcholine. Shows a high enzymatic activity. Induces dermonecrosis, blood vessel permeability and platelet aggregation (PubMed:9790962). Is directly toxic to kidney (PubMed:16005484) and liver (PubMed:18765244). Also induces hemolysis in a complement-dependent manner (PubMed:9790962) as well as in a complement-independent manner. The hemolysis provoked in a complement-independent manner is composed of several steps. The toxin binds to erythrocyte membranes, hydrolyzes membrane phospholipids (sphingomyelin and lysophosphatidylcholine) thus generating metabolism products that cause hemolysis, probably by provoking an increase of calcium inside cells. The calcium influx is due to the opening of L-type calcium channels, since L-type calcium channel blockers inhibit calcium influx (PubMed:21590705).<ref>PMID:16005484</ref> <ref>PMID:18760322</ref> <ref>PMID:18765244</ref> <ref>PMID:19455508</ref> <ref>PMID:21590705</ref> <ref>PMID:9790962</ref>
==See Also==
==See Also==
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*[[Phospholipase D 3D structures|Phospholipase D 3D structures]]
*[[Sphingomyelinase|Sphingomyelinase]]
*[[Sphingomyelinase|Sphingomyelinase]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:021616057</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Loxosceles intermedia]]
[[Category: Loxosceles intermedia]]
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[[Category: Sphingomyelin phosphodiesterase D]]
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[[Category: Arni RK]]
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[[Category: Arni, R K.]]
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[[Category: Giuseppe PO]]
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[[Category: Giuseppe, P O.]]
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[[Category: Murakami MT]]
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[[Category: Murakami, M T.]]
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[[Category: Ullah A]]
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[[Category: Ullah, A.]]
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[[Category: Veiga SS]]
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[[Category: Veiga, S S.]]
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[[Category: Class ii pld]]
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[[Category: Hydrolase]]
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[[Category: Phospholipase d]]
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[[Category: Plc-like phosphodiesterase]]
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[[Category: Tim beta/alpha-barrel superfamily]]
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[[Category: Venom]]
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Current revision

Crystal structure of a class II phospholipase D from Loxosceles intermedia venom

PDB ID 3rlh

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