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3rm8

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[[Image:3rm8.jpg|left|200px]]
 
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==AMCase in complex with Compound 2==
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The line below this paragraph, containing "STRUCTURE_3rm8", creates the "Structure Box" on the page.
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<StructureSection load='3rm8' size='340' side='right'caption='[[3rm8]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3rm8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RM8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RM8 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RM8:2-METHYL-3-{[4-(PYRIDIN-2-YL)PIPERAZIN-1-YL]METHYL}-1H-INDOLE'>RM8</scene></td></tr>
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{{STRUCTURE_3rm8| PDB=3rm8 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rm8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rm8 OCA], [https://pdbe.org/3rm8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rm8 RCSB], [https://www.ebi.ac.uk/pdbsum/3rm8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rm8 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CHIA_HUMAN CHIA_HUMAN] Degrades chitin and chitotriose. May participate in the defense against nematodes, fungi and other pathogens. Plays a role in T-helper cell type 2 (Th2) immune response. Contributes to the response to IL-13 and inflammation in response to IL-13. Stimulates chemokine production by pulmonary epithelial cells. Protects lung epithelial cells against apoptosis and promotes phosphorylation of AKT1. Its function in the inflammatory response and in protecting cells against apoptosis is inhibited by allosamidin, suggesting that the function of this protein depends on carbohydrate binding.<ref>PMID:11085997</ref> <ref>PMID:18824549</ref> <ref>PMID:19342690</ref> <ref>PMID:19435888</ref>
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===AMCase in complex with Compound 2===
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==See Also==
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*[[Chitinase 3D structures|Chitinase 3D structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 20666458 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_20666458}}
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==About this Structure==
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[[3rm8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RM8 OCA].
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==Reference==
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<ref group="xtra">PMID:020666458</ref><references group="xtra"/>
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[[Category: Chitinase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Olland, A.]]
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[[Category: Large Structures]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Olland A]]

Current revision

AMCase in complex with Compound 2

PDB ID 3rm8

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