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3rnq
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the complex between the extracellular domains of mouse PD-1 mutant and PD-L2== | |
| + | <StructureSection load='3rnq' size='340' side='right'caption='[[3rnq]], [[Resolution|resolution]] 1.60Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3rnq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RNQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RNQ FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rnq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rnq OCA], [https://pdbe.org/3rnq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rnq RCSB], [https://www.ebi.ac.uk/pdbsum/3rnq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rnq ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PD1L2_MOUSE PD1L2_MOUSE] Involved in the costimulatory signal essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.<ref>PMID:11283156</ref> <ref>PMID:11224527</ref> <ref>PMID:12719480</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Cell death protein 3D structures|Cell death protein 3D structures]] | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Almo SC]] | ||
| + | [[Category: Lazar-Molnar E]] | ||
| + | [[Category: Nathenson SG]] | ||
| + | [[Category: Ramagopal UA]] | ||
Current revision
Crystal structure of the complex between the extracellular domains of mouse PD-1 mutant and PD-L2
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