3rt6

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[[Image:3rt6.png|left|200px]]
 
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==Fluorowillardiine bound to the ligand binding domain of GluA3==
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The line below this paragraph, containing "STRUCTURE_3rt6", creates the "Structure Box" on the page.
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<StructureSection load='3rt6' size='340' side='right'caption='[[3rt6]], [[Resolution|resolution]] 2.84&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3rt6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RT6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RT6 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.836&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FWD:2-AMINO-3-(5-FLUORO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC+ACID'>FWD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3rt6| PDB=3rt6 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rt6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rt6 OCA], [https://pdbe.org/3rt6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rt6 RCSB], [https://www.ebi.ac.uk/pdbsum/3rt6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rt6 ProSAT]</span></td></tr>
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</table>
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===Fluorowillardiine bound to the ligand binding domain of GluA3===
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== Function ==
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[https://www.uniprot.org/uniprot/GRIA3_RAT GRIA3_RAT] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate (By similarity).
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(as it appears on PubMed at http://www.pubmed.gov), where 21464198 is the PubMed ID number.
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{{ABSTRACT_PUBMED_21464198}}
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==About this Structure==
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[[3rt6]] is a 1 chain structure of [[Ionotropic Glutamate Receptors]] with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RT6 OCA].
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==See Also==
==See Also==
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*[[Ionotropic Glutamate Receptors]]
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*[[Glutamate receptor 3D structures|Glutamate receptor 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:021464198</ref><references group="xtra"/>
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[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Ahmed, A H.]]
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[[Category: Ahmed AH]]
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[[Category: Oswald, R E.]]
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[[Category: Oswald RE]]
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[[Category: Ampa receptor]]
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[[Category: Glur3]]
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[[Category: Glutamate receptor]]
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[[Category: Neurotransmitter receptor]]
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[[Category: S1s2]]
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[[Category: Transport protein]]
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Current revision

Fluorowillardiine bound to the ligand binding domain of GluA3

PDB ID 3rt6

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OCA

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