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3rue
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Alternative analogs as viable substrates of UDP-hexose 4-epimerases== | |
| - | + | <StructureSection load='3rue' size='340' side='right'caption='[[3rue]], [[Resolution|resolution]] 2.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3rue]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Plesiomonas_shigelloides Plesiomonas shigelloides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RUE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RUE FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> | |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rue FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rue OCA], [https://pdbe.org/3rue PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rue RCSB], [https://www.ebi.ac.uk/pdbsum/3rue PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rue ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GNE_PLESH GNE_PLESH] Catalyzes the epimerization of UDP-N-acetylglucosamine (UDP-GlcNAc) to UDP-N-acetylgalactosamine (UDP-GalNAc). Has very low epimerase activity with UDP-Glc and UDP-Gal. Plays a role in the biosynthesis of 2-acetamino-2-deoxy-L-altruronic acid, a building block of the O-antigen in bacterial lipopolysaccharide (LPS).<ref>PMID:12484781</ref> <ref>PMID:21810411</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Plesiomonas shigelloides]] | ||
| + | [[Category: Bhatt VS]] | ||
| + | [[Category: Guan W]] | ||
| + | [[Category: Wang PG]] | ||
Current revision
Alternative analogs as viable substrates of UDP-hexose 4-epimerases
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