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3rur
From Proteopedia
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| - | [[Image:3rur.jpg|left|200px]] | ||
| - | + | ==Staphylococcus aureus heme-bound selenomethionine-labeled IsdB-N2== | |
| - | + | <StructureSection load='3rur' size='340' side='right'caption='[[3rur]], [[Resolution|resolution]] 1.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3rur]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_N315 Staphylococcus aureus subsp. aureus N315]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RUR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RUR FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rur FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rur OCA], [https://pdbe.org/3rur PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rur RCSB], [https://www.ebi.ac.uk/pdbsum/3rur PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rur ProSAT]</span></td></tr> | |
| - | + | </table> | |
| - | + | == Function == | |
| - | + | [https://www.uniprot.org/uniprot/ISDB_STAAN ISDB_STAAN] Seems to function as the primary receptor for hemoglobin since its inactivation inhibits the ability of S.aureus to bind hemoglobin. Binds hemoglobin in a dose-dependent way. Required for S.aureus growth using hemoglobin as the sole iron source. Also required for virulence. IsdA and/or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity). | |
| - | + | __TOC__ | |
| - | == | + | </StructureSection> |
| - | [[3rur]] is a 4 chain structure with sequence from [ | + | [[Category: Large Structures]] |
| - | [[Category: Staphylococcus aureus subsp. aureus]] | + | [[Category: Staphylococcus aureus subsp. aureus N315]] |
| - | [[Category: Arrieta | + | [[Category: Arrieta AL]] |
| - | [[Category: Gaudin | + | [[Category: Gaudin CFM]] |
| - | [[Category: Grigg | + | [[Category: Grigg JC]] |
| - | [[Category: Murphy | + | [[Category: Murphy MEP]] |
Current revision
Staphylococcus aureus heme-bound selenomethionine-labeled IsdB-N2
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