3rvh

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (12:38, 14 March 2024) (edit) (undo)
 
(5 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3rvh.jpg|left|200px]]
 
-
<!--
+
==Crystal Structure of JMJD2A Complexed with Inhibitor==
-
The line below this paragraph, containing "STRUCTURE_3rvh", creates the "Structure Box" on the page.
+
<StructureSection load='3rvh' size='340' side='right'caption='[[3rvh]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3rvh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RVH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RVH FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.251&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HQ2:8-HYDROXY-3-(PIPERAZIN-1-YL)QUINOLINE-5-CARBOXYLIC+ACID'>HQ2</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
{{STRUCTURE_3rvh| PDB=3rvh | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rvh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rvh OCA], [https://pdbe.org/3rvh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rvh RCSB], [https://www.ebi.ac.uk/pdbsum/3rvh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rvh ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/KDM4A_HUMAN KDM4A_HUMAN] Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively.<ref>PMID:16024779</ref> <ref>PMID:16603238</ref> <ref>PMID:21694756</ref> Isoform 2: Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain.<ref>PMID:16024779</ref> <ref>PMID:16603238</ref> <ref>PMID:21694756</ref>
-
===Crystal Structure of JMJD2A Complexed with Inhibitor===
+
==See Also==
-
 
+
*[[Jumonji domain-containing protein 3D structures|Jumonji domain-containing protein 3D structures]]
-
 
+
== References ==
-
==About this Structure==
+
<references/>
-
[[3rvh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RVH OCA].
+
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Clifton, I J.]]
+
[[Category: Large Structures]]
-
[[Category: Heightman, T D.]]
+
[[Category: Clifton IJ]]
-
[[Category: Jadhav, A.]]
+
[[Category: Heightman TD]]
-
[[Category: King, O N.F.]]
+
[[Category: Jadhav A]]
-
[[Category: Maloney, D J.]]
+
[[Category: King ONF]]
-
[[Category: McDonough, M A.]]
+
[[Category: Maloney DJ]]
-
[[Category: Rai, G.]]
+
[[Category: McDonough MA]]
-
[[Category: Schofield, C J.]]
+
[[Category: Rai G]]
-
[[Category: Simeonov, A.]]
+
[[Category: Schofield CJ]]
-
[[Category: Tumber, A.]]
+
[[Category: Simeonov A]]
-
[[Category: 2-oxoglutarate]]
+
[[Category: Tumber A]]
-
[[Category: Alpha-ketoglutarate]]
+
-
[[Category: Chromatin regulator]]
+
-
[[Category: Demethylation]]
+
-
[[Category: Dioxygenase]]
+
-
[[Category: Iron]]
+
-
[[Category: Jmjc domain]]
+
-
[[Category: Nucleus]]
+
-
[[Category: Oxidoreductase]]
+
-
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
+
-
[[Category: Transcription]]
+

Current revision

Crystal Structure of JMJD2A Complexed with Inhibitor

PDB ID 3rvh

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3rvh"
Personal tools