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3ry6

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{{STRUCTURE_3ry6| PDB=3ry6 | SCENE= }}
 
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===Complex of fcgammariia (CD32) and the FC of human IGG1===
 
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{{ABSTRACT_PUBMED_21856937}}
 
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==Disease==
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==Complex of fcgammariia (CD32) and the FC of human IGG1==
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[[http://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN]] Defects in IGHG1 are a cause of multiple myeloma (MM) [MIM:[http://omim.org/entry/254500 254500]]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4.
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<StructureSection load='3ry6' size='340' side='right'caption='[[3ry6]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[3ry6]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RY6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RY6 FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/FCG2A_HUMAN FCG2A_HUMAN]] Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens.<ref>PMID:19011614</ref>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ry6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ry6 OCA], [https://pdbe.org/3ry6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ry6 RCSB], [https://www.ebi.ac.uk/pdbsum/3ry6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ry6 ProSAT]</span></td></tr>
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[[3ry6]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RY6 OCA].
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</table>
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== Disease ==
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==Reference==
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[https://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN] Defects in IGHG1 are a cause of multiple myeloma (MM) [MIM:[https://omim.org/entry/254500 254500]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4.
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<ref group="xtra">PMID:021856937</ref><references group="xtra"/><references/>
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== Function ==
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[https://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN]
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Farrugia, W.]]
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[[Category: Large Structures]]
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[[Category: Hogarth, P M.]]
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[[Category: Farrugia W]]
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[[Category: Ramsland, P A.]]
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[[Category: Hogarth PM]]
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[[Category: Scott, A M.]]
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[[Category: Ramsland PA]]
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[[Category: Cd32]]
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[[Category: Scott AM]]
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[[Category: Cell membrane]]
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[[Category: Fc receptor]]
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[[Category: Glycoprotein]]
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[[Category: High responder polymorphism]]
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[[Category: Human igg1]]
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[[Category: Igg-binding protein]]
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[[Category: Immune system]]
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[[Category: Immunoglobulin c region]]
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[[Category: Immunoglobulin domain]]
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[[Category: Immunoglobulin superfamily]]
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[[Category: Membrane]]
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[[Category: Phosphoprotein]]
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[[Category: Receptor]]
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[[Category: Therapeutic antibody]]
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[[Category: Transmembrane]]
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Current revision

Complex of fcgammariia (CD32) and the FC of human IGG1

PDB ID 3ry6

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